| pubmed-article:20921409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0752065 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C1523305 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:20921409 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:20921409 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:20921409 | pubmed:dateCreated | 2010-10-20 | lld:pubmed |
| pubmed-article:20921409 | pubmed:abstractText | Phagocytosis of apoptotic cells requires recognition of cell corpses followed by internalization and enclosure within plasma membrane-derived phagosomes. Phagosomes undergo maturation to generate phagolysosomes in which cell corpses are degraded; however, regulation of the maturation process is poorly understood. Here, we identified Rab GTPase 14, which regulates apoptotic cell degradation in Caenorhabditis elegans. rab-14 mutants accumulate many persistent cell corpses owing to defective cell corpse clearance. Loss of rab-14 function affects several steps of phagosome maturation including phagosomal acidification and phagolysosome formation. RAB-14 and UNC-108/RAB2 are recruited to phagosomes at a similar stage and function redundantly to regulate phagosome maturation. Three Rabs, RAB-14, UNC-108/RAB2, and RAB-7, act in sequential steps to control phagolysosome formation. RAB-14 and UNC-108 recruit lysosomes, whereas RAB-7 mediates fusion of lysosomes to phagosomes. Our data reveal the sequential action of Rab GTPases in regulating tethering, docking, and fusion of lysosomes to apoptotic cell-containing phagosomes. | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20921409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20921409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20921409 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20921409 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20921409 | pubmed:author | pubmed-author:ZhangJuanJ | lld:pubmed |
| pubmed-article:20921409 | pubmed:author | pubmed-author:WangXiaochenX | lld:pubmed |
| pubmed-article:20921409 | pubmed:author | pubmed-author:GuoPengfeiP | lld:pubmed |
| pubmed-article:20921409 | pubmed:author | pubmed-author:HuTianjingT | lld:pubmed |
| pubmed-article:20921409 | pubmed:author | pubmed-author:JiangShanyaS | lld:pubmed |
| pubmed-article:20921409 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20921409 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:20921409 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20921409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20921409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20921409 | pubmed:pagination | 18016-21 | lld:pubmed |
| pubmed-article:20921409 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:meshHeading | pubmed-meshheading:20921409... | lld:pubmed |
| pubmed-article:20921409 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20921409 | pubmed:articleTitle | Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. | lld:pubmed |
| pubmed-article:20921409 | pubmed:affiliation | School of Life Sciences, Peking University, Beijing 100871, China. | lld:pubmed |
| pubmed-article:20921409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20921409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
