| pubmed-article:20880961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20880961 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:20880961 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:20880961 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:20880961 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:20880961 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:20880961 | lifeskim:mentions | umls-concept:C0445450 | lld:lifeskim |
| pubmed-article:20880961 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20880961 | pubmed:dateCreated | 2010-12-24 | lld:pubmed |
| pubmed-article:20880961 | pubmed:abstractText | Cancer cells undergo multi-step processes in obtaining the ability to metastasize, and are constantly exposed to signals that induce apoptosis. Acquisition of anti-apoptotic properties by cancer cells is important for metastasis, and recent studies suggest that transforming growth factor (TGF)-? promotes the survival of certain types of cancer cells. Here, we found that in highly metastatic breast cancer cells, JygMC(A), JygMC(B) and 4T1, TGF-? ligands were produced in autocrine fashion. Pharmacological inhibition of endogenous TGF-? signalling by a TGF-? type I receptor kinase inhibitor in serum-free conditions increased the expression of BH3-only protein, Bim (also known as Bcl2-like 11) in JygMC(A) and JygMC(B) cells, and caused apoptotic cell death. We also found that induction of Bim by TGF-? was not observed in Foxc1 knocked-down cancer cells. These findings suggest that TGF-? plays a crucial role in the regulation of survival of certain types of cancer cells through the TGF-?-Foxc1-Bim pathway, and that specific inhibitors of TGF-? signalling might be useful as apoptosis inducers in breast cancer cells. | lld:pubmed |
| pubmed-article:20880961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20880961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20880961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20880961 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20880961 | pubmed:issn | 1756-2651 | lld:pubmed |
| pubmed-article:20880961 | pubmed:author | pubmed-author:MiyazonoKohei... | lld:pubmed |
| pubmed-article:20880961 | pubmed:author | pubmed-author:EhataShogoS | lld:pubmed |
| pubmed-article:20880961 | pubmed:author | pubmed-author:KatsunoYokoY | lld:pubmed |
| pubmed-article:20880961 | pubmed:author | pubmed-author:HoshinoYukari... | lld:pubmed |
| pubmed-article:20880961 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20880961 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:20880961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20880961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20880961 | pubmed:pagination | 55-65 | lld:pubmed |
| pubmed-article:20880961 | pubmed:meshHeading | pubmed-meshheading:20880961... | lld:pubmed |
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| pubmed-article:20880961 | pubmed:meshHeading | pubmed-meshheading:20880961... | lld:pubmed |
| pubmed-article:20880961 | pubmed:meshHeading | pubmed-meshheading:20880961... | lld:pubmed |
| pubmed-article:20880961 | pubmed:meshHeading | pubmed-meshheading:20880961... | lld:pubmed |
| pubmed-article:20880961 | pubmed:meshHeading | pubmed-meshheading:20880961... | lld:pubmed |
| pubmed-article:20880961 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20880961 | pubmed:articleTitle | Autocrine TGF-? protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim. | lld:pubmed |
| pubmed-article:20880961 | pubmed:affiliation | Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. | lld:pubmed |
| pubmed-article:20880961 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20880961 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
