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pubmed-article:20870038pubmed:abstractTextRecently, we demonstrated that ajmaline caused ST segment elevation in the heart of an SCN5A mutation carrier by excitation failure in structurally discontinuous myocardium. In patients with Brugada syndrome, ST segment elevation is modulated by cardiac sodium (I(Na)), transient outward (I(to)), and L-type calcium currents (I(CaL)).lld:pubmed
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pubmed-article:20870038pubmed:copyrightInfoCopyright © 2011 Heart Rhythm Society. All rights reserved.lld:pubmed
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pubmed-article:20870038pubmed:articleTitleST segment elevation by current-to-load mismatch: an experimental and computational study.lld:pubmed
pubmed-article:20870038pubmed:affiliationDepartment of Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.g.hoogendijk@amc.uva.nllld:pubmed
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