| pubmed-article:20868680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C0019360 | lld:lifeskim |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C1423674 | lld:lifeskim |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20868680 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20868680 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:20868680 | pubmed:dateCreated | 2010-10-25 | lld:pubmed |
| pubmed-article:20868680 | pubmed:abstractText | With the aim of discovering new molecular interactions of the tight junction protein ZO-2, a two-hybrid screen was performed on a human kidney cDNA library using as bait the middle segment of ZO-2. Through this assay we identified a 24-kDa novel protein herein named ZASP for ZO-2 associated speckle protein. ZO-2/ZASP interaction further confirmed by pull down and immunoprecipitation experiments, requires the presence of the intact PDZ binding motif SQV of ZASP and the third PDZ domain of ZO-2. ZASP mRNA and protein are present in the kidney and in several epithelial cell lines. Endogenous ZASP is expressed primarily in nuclear speckles in co-localization with splicing factor SC-35. Nocodazole treatment and wash out reveals that ZASP disappears from the nucleus during mitosis in accordance with speckle disassembly during metaphase. ZASP amino acid sequence exhibits a canonical nuclear exportation signal and in agreement the protein exits the nucleus through a process mediated by exportin/CRM1. ZASP over-expression blocks the inhibitory activity of ZO-2 on cyclin D1 gene transcription and protein expression. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds. | lld:pubmed |
| pubmed-article:20868680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20868680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20868680 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20868680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20868680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20868680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20868680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20868680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20868680 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20868680 | pubmed:issn | 1090-2422 | lld:pubmed |
| pubmed-article:20868680 | pubmed:author | pubmed-author:González-Mari... | lld:pubmed |
| pubmed-article:20868680 | pubmed:author | pubmed-author:HuertaMiriamM | lld:pubmed |
| pubmed-article:20868680 | pubmed:author | pubmed-author:Lopez-Bayghen... | lld:pubmed |
| pubmed-article:20868680 | pubmed:author | pubmed-author:AlarcónLourde... | lld:pubmed |
| pubmed-article:20868680 | pubmed:author | pubmed-author:LechugaSusana... | lld:pubmed |
| pubmed-article:20868680 | pubmed:author | pubmed-author:SolanoJesúsJ | lld:pubmed |
| pubmed-article:20868680 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20868680 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20868680 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20868680 | pubmed:volume | 316 | lld:pubmed |
| pubmed-article:20868680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20868680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20868680 | pubmed:pagination | 3124-39 | lld:pubmed |
| pubmed-article:20868680 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20868680 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20868680 | pubmed:articleTitle | Identification of ZASP, a novel protein associated to Zona occludens-2. | lld:pubmed |
| pubmed-article:20868680 | pubmed:affiliation | Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), México, DF 07360, Mexico. | lld:pubmed |
| pubmed-article:20868680 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20868680 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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