| pubmed-article:20864524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0206188 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20864524 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:20864524 | pubmed:issue | 48 | lld:pubmed |
| pubmed-article:20864524 | pubmed:dateCreated | 2010-11-24 | lld:pubmed |
| pubmed-article:20864524 | pubmed:abstractText | One of the important questions in the field of virus research is about the balance between latent and lytic cycles of replication. Kaposi's sarcoma-associated herpesvirus (KSHV) remains predominantly in a latent state, with only 1-3% of cells supporting a lytic replication at any time. KSHV glycoprotein B (gB) is expressed not only on the virus envelope but also on the surfaces of the few cells supporting lytic replication. Using co-culture experiments, we determined that expression of KSHV gB on as few as 1-2% of human dermal microvascular endothelial cells resulted in a 10-fold inhibition of expression of ORF50, a viral gene critical for the onset of lytic replication. Also, we demonstrate that such a profound inhibitory effect of gB on the lytic cycle of virus replication is by repressing the ability of Egr-1 (early growth response-1) to bind and activate the ORF50 promoter. In general, virus-encoded late stage structural proteins, such as gB, are said to play major roles in virus entry and egress. The present report provides initial evidence supporting a role for membrane-associated gB expressed in a minimal number of cells to promote virus latency. These findings may have ramifications leading to a better understanding of the role of virus-encoded structural proteins not only in KSHV-related diseases but also in other viruses causing latent infections. | lld:pubmed |
| pubmed-article:20864524 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20864524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20864524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20864524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20864524 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20864524 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:20864524 | pubmed:author | pubmed-author:AkulaShaw MSM | lld:pubmed |
| pubmed-article:20864524 | pubmed:author | pubmed-author:DysonOssie... | lld:pubmed |
| pubmed-article:20864524 | pubmed:author | pubmed-author:TraylenChrist... | lld:pubmed |
| pubmed-article:20864524 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20864524 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:20864524 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:20864524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20864524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20864524 | pubmed:pagination | 37491-502 | lld:pubmed |
| pubmed-article:20864524 | pubmed:dateRevised | 2011-1-6 | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:meshHeading | pubmed-meshheading:20864524... | lld:pubmed |
| pubmed-article:20864524 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20864524 | pubmed:articleTitle | Cell membrane-bound Kaposi's sarcoma-associated herpesvirus-encoded glycoprotein B promotes virus latency by regulating expression of cellular Egr-1. | lld:pubmed |
| pubmed-article:20864524 | pubmed:affiliation | Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA. | lld:pubmed |
| pubmed-article:20864524 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20864524 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:1958 | entrezgene:pubmed | pubmed-article:20864524 | lld:entrezgene |
| entrez-gene:4961501 | entrezgene:pubmed | pubmed-article:20864524 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20864524 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20864524 | lld:entrezgene |
