| pubmed-article:20863547 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C1516670 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C1413357 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20863547 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20863547 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20863547 | pubmed:dateCreated | 2010-10-11 | lld:pubmed |
| pubmed-article:20863547 | pubmed:abstractText | Here we investigate the mechanisms by which HTLV-1 infection prevents the cell death of CD8(+) T cells in vivo. We show that upon natural infection, cloned CD8(+) but not CD4(+) cells from patients without malignancy become resistant to Fas-mediated cell death and acquire an antiapoptotic transcriptome that includes the overexpression of cIAP-2 and c-FLIP(L). CD8(+) lymphocyte-restricted cIAP-2 overexpression correlates with resistance to Fas-mediated apoptosis and depends on tax expression via NF-KappaB. In contrast, in the same CD8(+) cells, the HTLV-1-dependent overexpression of c-FLIP(L) does not correlate with resistance to Fas-mediated cell death nor with tax expression. In the present model, infected CD8(+) clones are the only cell subtype in which cIAP-2 expression correlates with resistance to cell death. These results support a role for Tax-dependent cIAP-2 expression in preventing the death of naturally infected CD8(+) cells and thereby in their clonal expansion in vivo. | lld:pubmed |
| pubmed-article:20863547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20863547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863547 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20863547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20863547 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20863547 | pubmed:issn | 1096-0341 | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:GessainAntoin... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:GoutOlivierO | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:Delfau-LarueM... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:WierinckxAnne... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:WattelEricE | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:MehlenPatrick... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:LegrasCatheri... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:MortreuxFranc... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:SibonDavidD | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:PinatelChrist... | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:LachuerJoëlJ | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:LançonAgnèsA | lld:pubmed |
| pubmed-article:20863547 | pubmed:author | pubmed-author:ZaneLindaL | lld:pubmed |
| pubmed-article:20863547 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20863547 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20863547 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:20863547 | pubmed:volume | 407 | lld:pubmed |
| pubmed-article:20863547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20863547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20863547 | pubmed:pagination | 341-51 | lld:pubmed |
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| pubmed-article:20863547 | pubmed:meshHeading | pubmed-meshheading:20863547... | lld:pubmed |
| pubmed-article:20863547 | pubmed:meshHeading | pubmed-meshheading:20863547... | lld:pubmed |
| pubmed-article:20863547 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20863547 | pubmed:articleTitle | Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression. | lld:pubmed |
| pubmed-article:20863547 | pubmed:affiliation | CNRS UMR5239, Université de Lyon, Oncovirologie et Biothérapies, Centre Léon Bérard, 69008 Lyon, France. | lld:pubmed |
| pubmed-article:20863547 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20863547 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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