| pubmed-article:20851648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20851648 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:20851648 | lifeskim:mentions | umls-concept:C0043012 | lld:lifeskim |
| pubmed-article:20851648 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20851648 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20851648 | pubmed:dateCreated | 2011-1-17 | lld:pubmed |
| pubmed-article:20851648 | pubmed:abstractText | The histaminergic system is exclusively localized within the posterior hypothalamus with projection to almost all the major regions of the central nervous system. Strong and consistent evidence exist to suggest that histamine, acting via H? and/or H? receptor has a pivotal role in the regulation of sleep-wakefulness. Administration of histamine or H? receptor agonists induces wakefulness, whereas administration of H? receptor antagonists promotes sleep. The H? receptor functions as an auto-receptor and regulates the synthesis and release of histamine. Activation of H? receptor reduces histamine release and promotes sleep. Conversely, blockade of H? receptor promotes wakefulness. Histamine release in the hypothalamus and other target regions is highest during wakefulness. The histaminergic neurons display maximal activity during the state of high vigilance, and cease their activity during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. The cerebrospinal levels of histamine are reduced in diseased states where hypersomnolence is a major symptom. The histamine deficient L-histidine decarboxylase knockout (HDC KO) mice display sleep fragmentation and increased REM sleep during the light period along with profound wakefulness deficit at dark onset, and in novel environment. Similar results have been obtained when histamine neurons are lesioned. These studies strongly implicate the histaminergic neurons of the TMN to play a critical role in the maintenance of high vigilance state during wakefulness. | lld:pubmed |
| pubmed-article:20851648 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20851648 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20851648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20851648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20851648 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20851648 | pubmed:issn | 1532-2955 | lld:pubmed |
| pubmed-article:20851648 | pubmed:author | pubmed-author:ThakkarMahesh... | lld:pubmed |
| pubmed-article:20851648 | pubmed:copyrightInfo | Published by Elsevier Ltd. | lld:pubmed |
| pubmed-article:20851648 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20851648 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:20851648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20851648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20851648 | pubmed:pagination | 65-74 | lld:pubmed |
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| pubmed-article:20851648 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20851648 | pubmed:articleTitle | Histamine in the regulation of wakefulness. | lld:pubmed |
| pubmed-article:20851648 | pubmed:affiliation | Neurology, University of Missouri, Harry S. Truman Memorial Veterans Hospital, Research, Room A023, 800 Hospital Drive, Columbia, MO 65210, USA. thakkarmm@health.missouri.edu | lld:pubmed |
| pubmed-article:20851648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20851648 | pubmed:publicationType | Review | lld:pubmed |
