| pubmed-article:20838588 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20838588 | lifeskim:mentions | umls-concept:C0024530 | lld:lifeskim |
| pubmed-article:20838588 | lifeskim:mentions | umls-concept:C0030498 | lld:lifeskim |
| pubmed-article:20838588 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:20838588 | lifeskim:mentions | umls-concept:C0441722 | lld:lifeskim |
| pubmed-article:20838588 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:20838588 | pubmed:dateCreated | 2010-9-14 | lld:pubmed |
| pubmed-article:20838588 | pubmed:abstractText | Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ?23 Mb genomes encoding ?5200 protein-coding genes. The protein-coding genes comprise about half of these genomes. Although evolutionary processes have a significant impact on malaria control, the selective pressures within Plasmodium genomes are poorly understood, particularly in the non-protein-coding portion of the genome. We use evolutionary methods to describe selective processes in both the coding and non-coding regions of these genomes. Based on genome alignments of seven Plasmodium species, we show that protein-coding, intergenic and intronic regions are all subject to purifying selection and we identify 670 conserved non-genic elements. We then use genome-wide polymorphism data from P. falciparum to describe short-term selective processes in this species and identify some candidate genes for balancing (diversifying) selection. Our analyses suggest that there are many functional elements in the non-genic regions of these genomes and that adaptive evolution has occurred more frequently in the protein-coding regions of the genome. | lld:pubmed |
| pubmed-article:20838588 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20838588 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20838588 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20838588 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20838588 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20838588 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20838588 | pubmed:issn | 1553-7404 | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:PainArnabA | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:DermitzakisEm... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:BerrimanMatth... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:KroghAndersA | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:McAuliffeJonJ | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:GardnerPaul... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:JeffaresDanie... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:NygaardSanneS | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:OttoThomas... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:BraunsteinAle... | lld:pubmed |
| pubmed-article:20838588 | pubmed:author | pubmed-author:MalsenGarethG | lld:pubmed |
| pubmed-article:20838588 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20838588 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:20838588 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20838588 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20838588 | pubmed:dateRevised | 2011-3-11 | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:meshHeading | pubmed-meshheading:20838588... | lld:pubmed |
| pubmed-article:20838588 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20838588 | pubmed:articleTitle | Long- and short-term selective forces on malaria parasite genomes. | lld:pubmed |
| pubmed-article:20838588 | pubmed:affiliation | Bioinformatics Centre, University of Copenhagen, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:20838588 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20838588 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
