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20837759

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pubmed-article:20837759pubmed:dateCreated2010-11-15lld:pubmed
pubmed-article:20837759pubmed:abstractTextInfections with Salmonella enterica serovar Typhi isolates that have reduced susceptibility to ofloxacin (MIC ? 0.25 ?g/ml) or ciprofloxacin (MIC ? 0.125 ?g/ml) have been associated with a delayed response or clinical failure following treatment with these antimicrobials. These isolates are not detected as resistant using current disk susceptibility breakpoints. We examined 816 isolates of S. Typhi from seven Asian countries. Screening for nalidixic acid resistance (MIC ? 16 ?g/ml) identified isolates with an ofloxacin MIC of ?0.25 ?g/ml with a sensitivity of 97.3% (253/260) and specificity of 99.3% (552/556). For isolates with a ciprofloxacin MIC of ?0.125 ?g/ml, the sensitivity was 92.9% (248/267) and specificity was 98.4% (540/549). A zone of inhibition of ?28 mm around a 5-?g ofloxacin disc detected strains with an ofloxacin MIC of ?0.25 ?g/ml with a sensitivity of 94.6% (246/260) and specificity of 94.2% (524/556). A zone of inhibition of ?30 mm detected isolates with a ciprofloxacin MIC of ?0.125 ?g/ml with a sensitivity of 94.0% (251/267) and specificity of 94.2% (517/549). An ofloxacin MIC of ?0.25 ?g/ml and a ciprofloxacin MIC of ?0.125 ?g/ml detected 74.5% (341/460) of isolates with an identified quinolone resistance-inducing mutation and 81.5% (331/406) of the most common mutant (carrying a serine-to-phenylalanine mutation at codon 83 in the gyrA gene). Screening for nalidixic acid resistance or ciprofloxacin and ofloxacin disk inhibition zone are suitable for detecting S. Typhi isolates with reduced fluoroquinolone susceptibility.lld:pubmed
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pubmed-article:20837759pubmed:year2010lld:pubmed
pubmed-article:20837759pubmed:articleTitleSuitable disk antimicrobial susceptibility breakpoints defining Salmonella enterica serovar Typhi isolates with reduced susceptibility to fluoroquinolones.lld:pubmed
pubmed-article:20837759pubmed:affiliationThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam. cmparry59@gmail.comlld:pubmed
pubmed-article:20837759pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20837759pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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