| pubmed-article:20835230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C0063684 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C1424250 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C1415831 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:20835230 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:20835230 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20835230 | pubmed:dateCreated | 2010-9-21 | lld:pubmed |
| pubmed-article:20835230 | pubmed:abstractText | Interleukin 1? (IL-1?) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1?. One therapy for type 2 diabetes, glyburide, suppressed IAPP-mediated IL-1? production in vitro. Processing of IL-1? initiated by IAPP first required priming, a process that involved glucose metabolism and was facilitated by minimally oxidized low-density lipoprotein. Finally, mice transgenic for human IAPP had more IL-1? in pancreatic islets, which localized together with amyloid and macrophages. Our findings identify previously unknown mechanisms in the pathogenesis of type 2 diabetes and treatment of pathology caused by IAPP. | lld:pubmed |
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| pubmed-article:20835230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20835230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20835230 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20835230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20835230 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20835230 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:YodoiJunjiJ | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:O'NeillLuke... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:MillsKingston... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:KahnSteven... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:ChenZheZ | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:NuñezGabrielG | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:HarrisJamesJ | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:BeckerChristi... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:HullRebecca... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:NewsholmePhil... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:FranchiLuigiL | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:DunneAislingA | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:LavelleEd CEC | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:MokK HunKH | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:MielkeLisa... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:MastersSeth... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:YoshiharaEiji... | lld:pubmed |
| pubmed-article:20835230 | pubmed:author | pubmed-author:TannahillGill... | lld:pubmed |
