Linked Life Data

20817832

Source:http://linkedlifedata.com/resource/pubmed/id/20817832

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pubmed-article:20817832pubmed:abstractTextThe previous studies in our laboratory revealed that seven cysteine mutants of apolipoprotein A-I (apoA-I) have different structural features and biological activities in vitro and in vivo. To investigate the potential cardioprotective effects of apolipoprotein A-I(N74C) [apoA-I(N74C)], we examined the anti-inflammatory, antioxidant, and antiatherosclerotic effects of this cysteine mutant in a rapid atherosclerosis model induced by perivascular carotid collar placement in apoE?/? mice. Lipid-free apoA-I(N74C) showed a significant increased antioxidant potency in low density lipoprotein (LDL) oxidation in vitro and reduced intracellular lipid accumulation in THP-1-derived macrophages, relative to wild-type apoA-I (apoA-Iwt). Mice injected with recombinant HDL (rHDL) reconstituted with apoA-I(N74C) (named rHDL74) through tail veins (40 mg/kg of body weight, three injections) had a significant lower level of serum interleukin-6 (IL-6) and enhanced serum antioxidation compared with mice receiving rHDL reconstituted with apoA-Iwt (named rHDLwt). Moreover, compared with rHDLwt, the rHDL74 in vivo injection resulted in a significant decrease in plaque size, ratio of aorta intima to media, arterial remodeling, and macrophage content in lesions. In summary, intravenous injection with rHDL74 reconstituted with apoA-I cysteine mutant apoA-I (N74C) dramatically delays the development of atherosclerosis induced by perivascular carotid collar placement and reduces vascular remodeling in the carotid artery in apoE?/? mice.lld:pubmed
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pubmed-article:20817832pubmed:authorpubmed-author:ZhangXinboXlld:pubmed
pubmed-article:20817832pubmed:authorpubmed-author:ChenBaoshengBlld:pubmed
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pubmed-article:20817832pubmed:year2010lld:pubmed
pubmed-article:20817832pubmed:articleTitleInhibition of collar-induced carotid atherosclerosis by recombinant apoA-I cysteine mutants in apoE-deficient mice.lld:pubmed
pubmed-article:20817832pubmed:affiliationNational Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.lld:pubmed
pubmed-article:20817832pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20817832pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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