| pubmed-article:20810985 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20810985 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20810985 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:20810985 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:20810985 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:20810985 | lifeskim:mentions | umls-concept:C0205275 | lld:lifeskim |
| pubmed-article:20810985 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:20810985 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20810985 | pubmed:dateCreated | 2010-9-22 | lld:pubmed |
| pubmed-article:20810985 | pubmed:abstractText | EBV infection is associated with development of the autoimmune disease systemic lupus erythematosus (SLE), and EBV can reactivate during SLE flares. Latent membrane protein 1 (LMP1) is an EBV-encoded oncogenic mimic of CD40 that can be re-expressed in PBMCs during SLE flares, as >90% of humans are latently EBV-infected. Whether LMP1 signaling exacerbates SLE is unknown. The phenotype of mice expressing a chimeric molecule with the mouse CD40 extracellular domain and the LMP1 intracellular signaling regions (mCD40-LMP1 transgenic [tg]) includes enhanced autoreactivity, yet these mice do not develop fatal autoimmune disease. We hypothesized that LMP1-mediated activation signals cooperate with and/or amplify events that predispose individuals to development of autoimmunity. To determine which aspects of autoimmunity may be exacerbated by LMP1, we bred mCD40-LMP1tg mice to two lupus-prone strains, B6.Sle1 and B6.Sle3, and analyzed autoimmunity parameters. LMP1(+)Sle1(+/+) mice developed enlarged lymphoid organs containing increased frequencies of germinal center, B cells, CD86(+) B cells, and activated and memory T cells compared with non-tg littermates. Anti-histone Abs were elevated in serum of LMP1(+)Sle1(+/+) mice, and they had signs of kidney pathology. LMP1(+)Sle1(+/+) B cells produced increased IL-6 and upregulated CD86 to a higher degree following CD40 stimulation in vitro, suggesting that the in vivo autoimmune exacerbation is B cell intrinsic. In contrast, the LMP1 transgene has no additional effects on autoimmunity on the B6.Sle3 background. These data indicate that LMP1-induced effects can cooperate with distinct subsets of host genes that predispose to autoimmunity and can thus be an exacerbating factor in autoimmune disease via multiple mechanisms. | lld:pubmed |
| pubmed-article:20810985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20810985 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20810985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810985 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20810985 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20810985 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:20810985 | pubmed:author | pubmed-author:BishopGail... | lld:pubmed |
| pubmed-article:20810985 | pubmed:author | pubmed-author:StunzLaura... | lld:pubmed |
| pubmed-article:20810985 | pubmed:author | pubmed-author:MeyerholzDavi... | lld:pubmed |
| pubmed-article:20810985 | pubmed:author | pubmed-author:MohanChandraC | lld:pubmed |
| pubmed-article:20810985 | pubmed:author | pubmed-author:PetersAnna... | lld:pubmed |
| pubmed-article:20810985 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20810985 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20810985 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:20810985 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20810985 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20810985 | pubmed:pagination | 4053-62 | lld:pubmed |
| pubmed-article:20810985 | pubmed:dateRevised | 2011-7-27 | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
| pubmed-article:20810985 | pubmed:meshHeading | pubmed-meshheading:20810985... | lld:pubmed |
