| pubmed-article:20810734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0887913 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0300423 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C1332729 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20810734 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:20810734 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:20810734 | pubmed:dateCreated | 2010-10-8 | lld:pubmed |
| pubmed-article:20810734 | pubmed:abstractText | Hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) are severe diseases associated with hantavirus infection. High levels of virus replication occur in microvascular endothelial cells but without a virus-induced cytopathic effect. However, virus infection results in microvascular leakage, which is the hallmark of these diseases. VE-cadherin is a major component of adherens junctions, and its interaction with the vascular endothelial growth factor (VEGF) receptor, VEGF-R2, is important for maintaining the integrity of the endothelial barrier. Here we report that increased secreted VEGF and concomitant decreased VE-cadherin are seen at early times postinfection of human primary lung endothelial cells with an HPS-associated hantavirus, Andes virus. Furthermore, active virus replication results in increased permeability and loss of the integrity of the endothelial cell barrier. VEGF binding to VEGF-R2 is known to result in dissociation of VEGF-R2 from VE-cadherin and in VE-cadherin activation, internalization, and degradation. Consistent with this, we showed that an antibody which blocks VEGF-R2 activation resulted in inhibition of the Andes virus-induced VE-cadherin reduction. These data implicate virus induction of VEGF and reduction in VE-cadherin in the endothelial cell permeability seen in HPS and suggest potential immunotherapeutic targets for the treatment of the disease. | lld:pubmed |
| pubmed-article:20810734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20810734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810734 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20810734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20810734 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20810734 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:20810734 | pubmed:author | pubmed-author:RollinPierre... | lld:pubmed |
| pubmed-article:20810734 | pubmed:author | pubmed-author:SpiropoulouCh... | lld:pubmed |
| pubmed-article:20810734 | pubmed:author | pubmed-author:Shrivastava-R... | lld:pubmed |
| pubmed-article:20810734 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20810734 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:20810734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20810734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20810734 | pubmed:pagination | 11227-34 | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:meshHeading | pubmed-meshheading:20810734... | lld:pubmed |
| pubmed-article:20810734 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20810734 | pubmed:articleTitle | Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin. | lld:pubmed |
| pubmed-article:20810734 | pubmed:affiliation | Special Pathogens Branch, G-14, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. | lld:pubmed |
| pubmed-article:20810734 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:7422 | entrezgene:pubmed | pubmed-article:20810734 | lld:entrezgene |
| entrez-gene:1003 | entrezgene:pubmed | pubmed-article:20810734 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20810734 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20810734 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20810734 | lld:pubmed |
