| pubmed-article:20805300 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C0678793 | lld:lifeskim |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:20805300 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:20805300 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:20805300 | pubmed:dateCreated | 2010-10-4 | lld:pubmed |
| pubmed-article:20805300 | pubmed:abstractText | Antibody drug conjugates (ADCs) combine the ideal properties of both antibodies and cytotoxic drugs by targeting potent drugs to the antigen-expressing tumor cells, thereby enhancing their antitumor activity. Successful ADC development for a given target antigen depends on optimization of antibody selection, linker stability, cytotoxic drug potency, and mode of linker-drug conjugation to the antibody. Here, we systematically examined the in vitro potency as well as in vivo preclinical efficacy and safety profiles of a heterogeneous preparation of conventional trastuzumab-mcc-DM1 (TMAb-mcc-DM1) ADC with that of a homogeneous engineered thio-trastuzumab-mpeo-DM1 (thioTMAb-mpeo-DM1) conjugate. Experimental Design and | lld:pubmed |
| pubmed-article:20805300 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20805300 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20805300 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20805300 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20805300 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:PolakisPaulP | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:DuggerDebra... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:SchellerRicha... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:LiGuangminG | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:SpencerSusan... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:SliwkowskiMar... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:GrahamRichard... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:TibbittsJayJ | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:MaiElaineE | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:HaEdwardE | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:NguyenTrungT | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:FujiReina NRN | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:VandlenRichar... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:JunutulaJagat... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:HiraragiHajim... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:RaabHelgaH | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:BhaktaSunilS | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:Lewis... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:ParsonsKathry... | lld:pubmed |
| pubmed-article:20805300 | pubmed:author | pubmed-author:FlagellaKelly... | lld:pubmed |
| pubmed-article:20805300 | pubmed:copyrightInfo | ©2010 AACR. | lld:pubmed |
| pubmed-article:20805300 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:20805300 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20805300 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:20805300 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20805300 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20805300 | pubmed:pagination | 4769-78 | lld:pubmed |
| pubmed-article:20805300 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
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| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:meshHeading | pubmed-meshheading:20805300... | lld:pubmed |
| pubmed-article:20805300 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20805300 | pubmed:articleTitle | Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer. | lld:pubmed |
| pubmed-article:20805300 | pubmed:affiliation | Genentech, Inc., South San Francisco, California 94080, USA. jagath@gene.com | lld:pubmed |
| pubmed-article:20805300 | pubmed:publicationType | Journal Article | lld:pubmed |
