| pubmed-article:20802536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C1420236 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:20802536 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:20802536 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20802536 | pubmed:dateCreated | 2011-1-6 | lld:pubmed |
| pubmed-article:20802536 | pubmed:abstractText | Although Wnt-Frizzled (Fzd) signaling is critical in the pathophysiology of carcinomas, its role in human breast cancer has been difficult to establish. We show here that the adaptor protein Na(+)/H(+) exchange regulatory factor1 (NHERF1), a protein abundantly expressed in normal mammary epithelium, regulates Wnt signaling, maintaining low levels of ?-catenin activation. NHERF1's effects are mediated by direct interactions between one of its PSD-95/drosophila discs large/ZO-1 (PDZ) domains and the C-terminus of a subset of Fzd receptors. Loss of NHERF1 in breast cancer cell lines enhances canonical Wnt signaling and Wnt-dependent cell proliferation. Furthermore, the mammary glands of NHERF1-knockout mice exhibit increased mammary duct density accompanied by increased proliferation and ?-catenin activity. Finally, we demonstrate a negative correlation between NHERF1 expression and nuclear ?-catenin in human breast carcinomas. Taken together, these results provide a novel insight into the regulation of Wnt signaling in normal and neoplastic breast tissues, and identify NHERF1 as an important regulator of the pathogenesis of breast tumors. | lld:pubmed |
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| pubmed-article:20802536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20802536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20802536 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20802536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20802536 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20802536 | pubmed:issn | 1476-5594 | lld:pubmed |
| pubmed-article:20802536 | pubmed:author | pubmed-author:RomeroGG | lld:pubmed |
| pubmed-article:20802536 | pubmed:author | pubmed-author:FriedmanP APA | lld:pubmed |
| pubmed-article:20802536 | pubmed:author | pubmed-author:WheelerD SDS | lld:pubmed |
| pubmed-article:20802536 | pubmed:author | pubmed-author:BrufskyA MAM | lld:pubmed |
| pubmed-article:20802536 | pubmed:author | pubmed-author:BarrickS RSR | lld:pubmed |
| pubmed-article:20802536 | pubmed:author | pubmed-author:GrubishaM JMJ | lld:pubmed |
| pubmed-article:20802536 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20802536 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:20802536 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:20802536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20802536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20802536 | pubmed:pagination | 32-42 | lld:pubmed |
| pubmed-article:20802536 | pubmed:dateRevised | 2011-11-11 | lld:pubmed |
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| pubmed-article:20802536 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20802536 | pubmed:articleTitle | Direct interaction between NHERF1 and Frizzled regulates ?-catenin signaling. | lld:pubmed |
| pubmed-article:20802536 | pubmed:affiliation | Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. | lld:pubmed |
| pubmed-article:20802536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20802536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20802536 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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