| pubmed-article:20797410 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20797410 | lifeskim:mentions | umls-concept:C0025611 | lld:lifeskim |
| pubmed-article:20797410 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:20797410 | lifeskim:mentions | umls-concept:C0728831 | lld:lifeskim |
| pubmed-article:20797410 | lifeskim:mentions | umls-concept:C0444706 | lld:lifeskim |
| pubmed-article:20797410 | lifeskim:mentions | umls-concept:C0040808 | lld:lifeskim |
| pubmed-article:20797410 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20797410 | pubmed:dateCreated | 2010-11-8 | lld:pubmed |
| pubmed-article:20797410 | pubmed:abstractText | Repeated administration of methamphetamine (mAMPH) to rodents in a single-day "binge" regimen damages forebrain monoaminergic nerve terminals and produces subsequent cognitive deficits. Here we investigate performance on a social odor-based task, demonstrating enduring mAMPH-induced deficits in recognition memory. Three weeks after a neurotoxic mAMPH regimen, singly-housed male Long-Evans rats had four wooden beads placed in their home cage: three beads containing odors from their home cage (HC beads) and one bead from a cage of a rat not present in the colony room (N1 bead). Exploration times for each bead were recorded during three 1-min habituation trials separated by 1-min intertrial intervals. Twenty-four hours later, a 1-min memory test was conducted, in which animals were presented with two HC beads, one N1 bead, and one bead from another novel animal (N2). Saline- and mAMPH-treated rats showed similar, progressive decreases in exploration time for the N1 bead during the habituation trials, indicating equivalent short-term olfactory habituation to the novel odor. By contrast, during the subsequent memory test, saline-treated rats showed a strong preference for the N2 bead over the N1 bead while mAMPH-treated rats showed no preference. The use of the rats' primary sensory modality (olfaction) coupled with the social significance (from conspecifics) of the odors produces strong, long-lasting memories. Our results show that prior treatment with a neurotoxic regimen of mAMPH impairs long-term memory for the previously experienced odors. As compared with previously employed object recognition tasks, this test may be advantageous for investigating mAMPH-induced memory impairments in rodents. | lld:pubmed |
| pubmed-article:20797410 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20797410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20797410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20797410 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20797410 | pubmed:issn | 1872-7549 | lld:pubmed |
| pubmed-article:20797410 | pubmed:author | pubmed-author:O'DellSteven... | lld:pubmed |
| pubmed-article:20797410 | pubmed:author | pubmed-author:MarshallJohn... | lld:pubmed |
| pubmed-article:20797410 | pubmed:author | pubmed-author:FeinbergLeila... | lld:pubmed |
| pubmed-article:20797410 | pubmed:copyrightInfo | Copyright © 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:20797410 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20797410 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20797410 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:20797410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20797410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20797410 | pubmed:pagination | 396-401 | lld:pubmed |
| pubmed-article:20797410 | pubmed:meshHeading | pubmed-meshheading:20797410... | lld:pubmed |
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| pubmed-article:20797410 | pubmed:meshHeading | pubmed-meshheading:20797410... | lld:pubmed |
| pubmed-article:20797410 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20797410 | pubmed:articleTitle | A neurotoxic regimen of methamphetamine impairs novelty recognition as measured by a social odor-based task. | lld:pubmed |
| pubmed-article:20797410 | pubmed:affiliation | Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, United States. sjodell@uci.edu | lld:pubmed |
| pubmed-article:20797410 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20797410 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
