| pubmed-article:20717897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C1367690 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C1426330 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C1428424 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:20717897 | lifeskim:mentions | umls-concept:C1549649 | lld:lifeskim |
| pubmed-article:20717897 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20717897 | pubmed:dateCreated | 2010-12-30 | lld:pubmed |
| pubmed-article:20717897 | pubmed:abstractText | G-protein-coupled receptor kinase 2 (GRK2) is a member of a kinase family originally discovered for its role in the phosphorylation and desensitization of G-protein-coupled receptors. It is expressed in high levels in myeloid cells and its levels are altered in many inflammatory disorders including sepsis. To address the physiological role of myeloid cell-specific GRK2 in inflammation, we generated mice bearing GRK2 deletion in myeloid cells (GRK2?mye). GRK2?mye mice exhibited exaggerated inflammatory cytokine/chemokine production, and organ injury in response to lipopolysaccharide (LPS, a TLR4 ligand) when compared to wild-type littermates (GRK2fl/fl). Consistent with this, peritoneal macrophages from GRK2?mye mice showed enhanced inflammatory cytokine levels when stimulated with LPS. Our results further identify TLR4-induced NF-?B1p105-ERK pathway to be selectively regulated by GRK2. LPS-induced activation of NF-?B1p105-MEK-ERK pathway is significantly enhanced in the GRK2?mye macrophages compared to GRK2fl/fl cells and importantly, inhibition of the p105 and ERK pathways in the GRK2?mye macrophages, limits the enhanced production of LPS-induced cytokines/chemokines. Taken together, our studies reveal previously undescribed negative regulatory role for GRK2 in TLR4-induced p105-ERK pathway as well as in the consequent inflammatory cytokine/chemokine production and endotoxemia in mice. | lld:pubmed |
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| pubmed-article:20717897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20717897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20717897 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20717897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20717897 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20717897 | pubmed:issn | 1097-4652 | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:AmalfitanoAnd... | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:DornGerald... | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:ParameswaranN... | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:PatialSonikaS | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:ParvataneniSi... | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:SenagorePatri... | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:AppledornDani... | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:SainiYogeshY | lld:pubmed |
| pubmed-article:20717897 | pubmed:author | pubmed-author:LapresJohn... | lld:pubmed |
| pubmed-article:20717897 | pubmed:copyrightInfo | Copyright © 2010 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:20717897 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20717897 | pubmed:volume | 226 | lld:pubmed |
| pubmed-article:20717897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20717897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20717897 | pubmed:pagination | 627-37 | lld:pubmed |
| pubmed-article:20717897 | pubmed:dateRevised | 2011-6-6 | lld:pubmed |
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| pubmed-article:20717897 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20717897 | pubmed:articleTitle | Myeloid-specific GPCR kinase-2 negatively regulates NF-?B1p105-ERK pathway and limits endotoxemic shock in mice. | lld:pubmed |
| pubmed-article:20717897 | pubmed:affiliation | Department of Physiology and Division of Pathology, Michigan State University, East Lansing, Michigan 48824, USA. | lld:pubmed |
| pubmed-article:20717897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20717897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20717897 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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