Source:http://linkedlifedata.com/resource/pubmed/id/20717795
| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:20717795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20717795 | lifeskim:mentions | umls-concept:C0031090 | lld:lifeskim |
| pubmed-article:20717795 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:20717795 | lifeskim:mentions | umls-concept:C0011900 | lld:lifeskim |
| pubmed-article:20717795 | lifeskim:mentions | umls-concept:C1519159 | lld:lifeskim |
| pubmed-article:20717795 | pubmed:dateCreated | 2010-8-18 | lld:pubmed |
| pubmed-article:20717795 | pubmed:abstractText | T cells recognize antigens via the T-cell receptor (TCR). Diversity in antigen recognition by T cells is generated in part by the recombination of V, (D), J, and C segments of the TCR. It is further enhanced by the N region, in addition to non-germline-encoded nucleotides at the V-(D)-J junction. It is generally believed that each T cell bears a distinct clonotype of TCR and that each clonotype is responsible for an antigen-specific T-cell response. T-cell clonal expansion has been detected in the peripheral blood or the disease-affected sites in patients with infections, autoimmune diseases, malignancy, and post-transplantation complications. Since antigen stimulation of T cells induces the proliferation of specific T cells, clonal T-cell expansion is considered to be a result of an antigen-specific immune response. For the analysis of such antigen-specific T cells, it is common to use their specific antigens if they are known. However, there are many diseases, such as periodontal diseases, in which there are a number of putative pathogenic antigens involved. In these circumstances, the detection of clonally expanded T cells is an effective method to evaluate whether antigen-specific immune responses are involved, since only a few clonally expanded T cells are detected in healthy individuals. In addition, the characterization of any clonally expanded T cells that are detected would further promote the understanding of the disease mechanisms. By using single-strand conformation polymorphism (SSCP) analysis, we demonstrated that oligoclonal T-cell accumulation was present in periodontitis lesions, in contrast to a heterogeneous T-cell population in the peripheral blood. SSCP is a powerful tool for analyzing specific T-cell responses both in vitro and in vivo. | lld:pubmed |
| pubmed-article:20717795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20717795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20717795 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20717795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20717795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20717795 | pubmed:issn | 1940-6029 | lld:pubmed |
| pubmed-article:20717795 | pubmed:author | pubmed-author:YamazakiKazuh... | lld:pubmed |
| pubmed-article:20717795 | pubmed:author | pubmed-author:ItoHarueH | lld:pubmed |
| pubmed-article:20717795 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20717795 | pubmed:volume | 666 | lld:pubmed |
| pubmed-article:20717795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20717795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20717795 | pubmed:pagination | 359-72 | lld:pubmed |
| pubmed-article:20717795 | pubmed:meshHeading | pubmed-meshheading:20717795... | lld:pubmed |
| pubmed-article:20717795 | pubmed:meshHeading | pubmed-meshheading:20717795... | lld:pubmed |
| pubmed-article:20717795 | pubmed:meshHeading | pubmed-meshheading:20717795... | lld:pubmed |
| pubmed-article:20717795 | pubmed:meshHeading | pubmed-meshheading:20717795... | lld:pubmed |
| pubmed-article:20717795 | pubmed:meshHeading | pubmed-meshheading:20717795... | lld:pubmed |
| pubmed-article:20717795 | pubmed:meshHeading | pubmed-meshheading:20717795... | lld:pubmed |
| pubmed-article:20717795 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20717795 | pubmed:articleTitle | Single-strand conformation polymorphism analysis for the diagnosis of T-cell clonality in periodontal disease. | lld:pubmed |
| pubmed-article:20717795 | pubmed:affiliation | Center for Transdisciplinary Research, Niigata University, Niigata, Japan. | lld:pubmed |
| pubmed-article:20717795 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20717795 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |