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pubmed-article:2071229pubmed:abstractTextCytogenetic analysis was performed on 11 benign and borderline ovarian tumors. Trisomy 12, identified as a sole abnormality in 6 tumors, is likely a specific karyotypic change in different benign and borderline tumors and may well be a primary chromosomal lesion in these tumors. The possible association between amplification of the proto-oncogene K-ras-2 which is located on chromosome 12 and trisomy 12 was investigated. DNA blotting analysis of 64 tumors indicates that trisomy 12 does not seem to be related to K-ras-2 amplification in ovarian tumors. K-ras-2 amplification was observed in 3 high-grade tumors from 3 patients with metastases.lld:pubmed
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pubmed-article:2071229pubmed:articleTitleTrisomy 12 and K-ras-2 amplification in human ovarian tumors.lld:pubmed
pubmed-article:2071229pubmed:affiliationDepartment of Human Genetics, Yale University School of Medicine, New Haven, CT 06510-8005.lld:pubmed
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pubmed-article:2071229pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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