Linked Life Data

2071154

Source:http://linkedlifedata.com/resource/pubmed/id/2071154

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pubmed-article:2071154pubmed:abstractTextThe JE gene, cloned from platelet-derived growth factor (PDGF)-treated mouse 3T3 cells, was the first PDGF-inducible gene to be described. Its human homolog (gene name "small inducible cytokine A2" [SCYA2]) encodes the monocyte specific chemotactic factor MCP-1 (or MCAF) which is structurally related to a recently described family of cytokines. By a combination of in situ hybridization and study of somatic cell hybrids, we have assigned the human SCYA2 gene to 17q11.2-12, the locus to which other members of this family have been mapped. We have also reconstructed a phylogenetic tree relating the members of this family to each other and to their murine homologs which suggests that these genes arose by duplication and divergence prior to the murine/human divergence. Four of the five members of this subfamily have now been assigned to the same locus (and the fifth to chromosome 17), while several of the members of a related gene family have been assigned to 4q. We propose that the two subfamilies be designated the 17q and 4q subfamilies.lld:pubmed
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pubmed-article:2071154pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:2071154pubmed:articleTitleAssignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus.lld:pubmed
pubmed-article:2071154pubmed:affiliationDivision of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.lld:pubmed
pubmed-article:2071154pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2071154pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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