Linked Life Data

20706607

Source:http://linkedlifedata.com/resource/pubmed/id/20706607

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pubmed-article:20706607pubmed:abstractTextNu-3 [butyl-phosphate-5'-thymidine-3'-phosphate-butyl] is a modified nucleotide that has been shown to have antimicrobial activity against a range of bacteria including Pseudomonas aeruginosa. However, data on the toxicological profile of Nu-3 are still lacking. In the present study, the toxicity of Nu-3 was evaluated by the following studies: acute oral toxicity, dermal and mucous membrane irritation, multiple-dose toxicity and genotoxicity in vivo and vitro. The acute oral toxicity test in mice showed that Nu-3 had an LD(50) of 2001 mg/kg body weight. The irritation tests on rats revealed that Nu-3 was not irritant, with an irritation scoring of 0. The multiple-dose toxicity study in rats showed that Nu-3 did not cause significant changes in histology, selected serum chemistry, and hematological parameters compared to the controls. Rats administrated with multiple-doses of Nu-3 showed no visible toxic symptoms. Both in vitro and in vivo, Nu-3 exhibited no notable genetic toxicity. Overall, the data suggest that Nu-3 is hypotoxic or nontoxic antimicrobial compound that warrants being further developed for treating Pseudomonas aeruginosa infection.lld:pubmed
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pubmed-article:20706607pubmed:authorpubmed-author:WangMingMlld:pubmed
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pubmed-article:20706607pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:20706607pubmed:articleTitleAcute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent.lld:pubmed
pubmed-article:20706607pubmed:affiliationCollege of Veterinary Medicine, China Agricultura University, Beijing 100193, China.lld:pubmed
pubmed-article:20706607pubmed:publicationTypeJournal Articlelld:pubmed