| pubmed-article:20705812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20705812 | lifeskim:mentions | umls-concept:C0019647 | lld:lifeskim |
| pubmed-article:20705812 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:20705812 | lifeskim:mentions | umls-concept:C0026255 | lld:lifeskim |
| pubmed-article:20705812 | lifeskim:mentions | umls-concept:C0007709 | lld:lifeskim |
| pubmed-article:20705812 | lifeskim:mentions | umls-concept:C0733755 | lld:lifeskim |
| pubmed-article:20705812 | lifeskim:mentions | umls-concept:C0768653 | lld:lifeskim |
| pubmed-article:20705812 | pubmed:issue | 6001 | lld:pubmed |
| pubmed-article:20705812 | pubmed:dateCreated | 2010-10-8 | lld:pubmed |
| pubmed-article:20705812 | pubmed:abstractText | Aurora B is a component of the chromosomal passenger complex (CPC) required for correct spindle-kinetochore attachments during chromosome segregation and for cytokinesis. The chromatin factors that recruit the CPC to centromeres are unknown, however. Here we show that phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin binds directly to H3T3ph. A nonbinding Survivin-D70A/D71A mutant does not support centromeric CPC concentration, and both Haspin depletion and Survivin-D70A/D71A mutation diminish centromere localization of the kinesin MCAK and the mitotic checkpoint response to taxol. Survivin-D70A/D71A mutation and microinjection of H3T3ph-specific antibody both compromise centromeric Aurora B functions but do not prevent cytokinesis. Therefore, H3T3ph generated by Haspin positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis. | lld:pubmed |
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| pubmed-article:20705812 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20705812 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20705812 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20705812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20705812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20705812 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20705812 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:OshJ AJA | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:StukenbergP... | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:GorbskyGary... | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:HigginsJonath... | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:DaumJohn RJR | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:WangFangweiF | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:Niedzialkowsk... | lld:pubmed |
| pubmed-article:20705812 | pubmed:author | pubmed-author:BanerjeeBudha... | lld:pubmed |
| pubmed-article:20705812 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20705812 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:20705812 | pubmed:volume | 330 | lld:pubmed |
| pubmed-article:20705812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20705812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20705812 | pubmed:pagination | 231-5 | lld:pubmed |
| pubmed-article:20705812 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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