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pubmed-article:20700414pubmed:dateCreated2010-8-11lld:pubmed
pubmed-article:20700414pubmed:abstractTextPyrrolepolyamide-2'-deoxyguanosine hybrids (Hybrid 2 and Hybrid 3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid 1). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2'-deoxyguanosine hybrids was performed by CD spectral and T(m) analyses. It was shown that Hybrid 3 possessed greater binding specificity than distamycin A, Hybrid 1 and Hybrid 2.lld:pubmed
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pubmed-article:20700414pubmed:languageenglld:pubmed
pubmed-article:20700414pubmed:statusPubMed-not-MEDLINElld:pubmed
pubmed-article:20700414pubmed:authorpubmed-author:KawashimaEtsu...lld:pubmed
pubmed-article:20700414pubmed:authorpubmed-author:OhbaYusukeYlld:pubmed
pubmed-article:20700414pubmed:authorpubmed-author:KamaikeKazuoKlld:pubmed
pubmed-article:20700414pubmed:authorpubmed-author:TeruiYusukeYlld:pubmed
pubmed-article:20700414pubmed:ownerNLMlld:pubmed
pubmed-article:20700414pubmed:authorsCompleteYlld:pubmed
pubmed-article:20700414pubmed:articleTitleDesign, synthesis, and analysis of minor groove binder pyrrolepolyamide-2'-deoxyguanosine hybrids.lld:pubmed
pubmed-article:20700414pubmed:affiliationSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.lld:pubmed
pubmed-article:20700414pubmed:publicationTypeJournal Articlelld:pubmed