| pubmed-article:20696888 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C0014072 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C1417695 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20696888 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:20696888 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:20696888 | pubmed:dateCreated | 2010-8-25 | lld:pubmed |
| pubmed-article:20696888 | pubmed:abstractText | Nuclear factor of activated T cells (NFAT) proteins are a group of Ca(2+)-regulated transcription factors residing in the cytoplasm of resting cells. Dephosphorylation by calcineurin results in nuclear translocation of NFAT and subsequent expression of target genes; rephosphorylation by kinases, including casein kinase 1 (CK1), restores NFAT to its latent state in the cytoplasm. We engineered a hyperactivable version of NFAT1 with increased affinity for calcineurin and decreased affinity for casein kinase 1. Mice expressing hyperactivable NFAT1 in their T-cell compartment exhibited a dramatically increased frequency of both IL-17- and IL-10-producing cells after differentiation under Th17 conditions-this was associated with direct binding of NFAT1 to distal regulatory regions of Il-17 and Il-10 gene loci in Th17 cells. Despite higher IL-17 production in culture, the mice were significantly less prone to myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis than controls, correlating with increased production of the immunomodulatory cytokine IL-10 and enhanced accumulation of regulatory T cells within the CNS. Thus, NFAT hyperactivation paradoxically leads to decreased susceptibility to experimental autoimmune encephalomyelitis, supporting previous observations linking defects in Ca(2+)/NFAT signaling to lymphoproliferation and autoimmune disease. | lld:pubmed |
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| pubmed-article:20696888 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20696888 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696888 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20696888 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20696888 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20696888 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:RaoAnjanaA | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:RajewskyKlaus... | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:MüllerMartin... | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:SundrudMark... | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:GhoshSrimoyee... | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:SasakiYoshite... | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:KoralovSergei... | lld:pubmed |
| pubmed-article:20696888 | pubmed:author | pubmed-author:StevanovicIre... | lld:pubmed |
| pubmed-article:20696888 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20696888 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:20696888 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20696888 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20696888 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20696888 | pubmed:pagination | 15169-74 | lld:pubmed |
| pubmed-article:20696888 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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