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pubmed-article:20693610pubmed:abstractTextHigh-throughput genomic technologies are increasingly being used to identify therapeutic targets and risk factors for specific diseases. Using 116 independent liver samples, we identified 793 probe sets that demonstrated a significant association in the frequency of absent calls as tissues progressed from normal to pre-neoplastic to neoplastic, followed by a bioinformatic approach which identified that 78.9% of the significant probe sets contained at least one CpG island in the gene promoter region compared with 58.9% of the remaining genes examined. Our results indicate that further high-throughput methylation studies to more fully characterize molecular events involved in hepatocarcinogenesis are warranted.lld:pubmed
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pubmed-article:20693610pubmed:year2010lld:pubmed
pubmed-article:20693610pubmed:articleTitleIdentifying genes progressively silenced in preneoplastic and neoplastic liver tissues.lld:pubmed
pubmed-article:20693610pubmed:affiliationDepartment of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298-0032, USA. kjarcher@vcu.edulld:pubmed
pubmed-article:20693610pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20693610pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed