| pubmed-article:20691153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0030281 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20691153 | lifeskim:mentions | umls-concept:C1261381 | lld:lifeskim |
| pubmed-article:20691153 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20691153 | pubmed:dateCreated | 2010-9-6 | lld:pubmed |
| pubmed-article:20691153 | pubmed:abstractText | Type 1 diabetes (T1D) is caused by a T cell-mediated autoimmune response that leads to the loss of insulin-producing beta cells. The optimal preclinical testing of promising therapies would be aided by a humanized immune-mediated T1D model. We develop this model in NOD-scid IL2rgamma(null) mice. The selective destruction of pancreatic islet beta cells was mediated by human T lymphocytes after an initial trigger was supplied by the injection of irradiated spleen mononuclear cells (SMC) from diabetic nonobese diabetic (NOD) mice. This resulted in severe insulitis, a marked loss of total beta-cell mass, and other related phenotypes of T1D. The migration of human T cells to pancreatic islets was controlled by the beta cell-produced highly conserved chemokine stromal cell-derived factor 1 (SDF-1) and its receptor C-X-C chemokine receptor (CXCR) 4, as demonstrated by in vivo blocking experiments using antibody to CXCR4. The specificity of humanized T cell-mediated immune responses against islet beta cells was generated by the local inflammatory microenvironment in pancreatic islets including human CD4(+) T cell infiltration and clonal expansion, and the mouse islet beta-cell-derived CD1d-mediated human iNKT activation. The selective destruction of mouse islet beta cells by a human T cell-mediated immune response in this humanized T1D model can mimic those observed in T1D patients. This model can provide a valuable tool for translational research into T1D. | lld:pubmed |
| pubmed-article:20691153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20691153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691153 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20691153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20691153 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20691153 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:BrenaR MRM | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:MihailescuDan... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:SkidgelRandal... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:MazzoneTheodo... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:ZhangYongkang... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:HoltermanMark... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:ZhaoYongY | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:SamSusanS | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:PrabhakarBell... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:HwangDavidD | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:JainSumitS | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:GuoChengshanC | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:SidhwaniSeema... | lld:pubmed |
| pubmed-article:20691153 | pubmed:author | pubmed-author:DingeldeinMic... | lld:pubmed |
| pubmed-article:20691153 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20691153 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20691153 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:20691153 | pubmed:volume | 399 | lld:pubmed |
| pubmed-article:20691153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20691153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20691153 | pubmed:pagination | 629-36 | lld:pubmed |
| pubmed-article:20691153 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:meshHeading | pubmed-meshheading:20691153... | lld:pubmed |
| pubmed-article:20691153 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20691153 | pubmed:articleTitle | Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. | lld:pubmed |
| pubmed-article:20691153 | pubmed:affiliation | Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. yongzhao@uic.edu | lld:pubmed |
| pubmed-article:20691153 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20691153 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16186 | entrezgene:pubmed | pubmed-article:20691153 | lld:entrezgene |
| entrez-gene:19090 | entrezgene:pubmed | pubmed-article:20691153 | lld:entrezgene |
