| pubmed-article:20691026 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0010583 | lld:lifeskim |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:20691026 | lifeskim:mentions | umls-concept:C0599724 | lld:lifeskim |
| pubmed-article:20691026 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20691026 | pubmed:dateCreated | 2010-8-9 | lld:pubmed |
| pubmed-article:20691026 | pubmed:abstractText | Median survival times (STs) for doxorubicin-treated canine lymphoma range from 5.7 to 9 months. Because dogs treated with multi-agent protocols have longer STs, we sought to evaluate whether adding cyclophosphamide would improve outcome in canine lymphoma patients while maintaining an acceptable level of toxicity. Thirty-two dogs with stage III-V multicentric lymphoma were treated with doxorubicin every 3 weeks for five total cycles and prednisone at a tapering dose for the first 4 weeks. Dogs were randomized to receive either cyclophosphamide or placebo concurrently. Seventeen dogs received doxorubicin and placebo, while 15 dogs received doxorubicin and cyclophosphamide. Response, toxicity, progression-free interval (PFI) and ST were evaluated. The combination of doxorubicin and cyclophosphamide was well tolerated, causing no increase in adverse events over doxorubicin alone. Despite a numeric improvement in outcome in cyclophosphamide treated dogs, the addition of cyclophosphamide did not result in statistically improved response rate, PFI or ST. | lld:pubmed |
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| pubmed-article:20691026 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20691026 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691026 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20691026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20691026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691026 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20691026 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20691026 | pubmed:issn | 1476-5829 | lld:pubmed |
| pubmed-article:20691026 | pubmed:author | pubmed-author:SteinT JTJ | lld:pubmed |
| pubmed-article:20691026 | pubmed:author | pubmed-author:ThammD HDH | lld:pubmed |
| pubmed-article:20691026 | pubmed:author | pubmed-author:LoriJ CJC | lld:pubmed |
| pubmed-article:20691026 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20691026 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:20691026 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20691026 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20691026 | pubmed:pagination | 188-95 | lld:pubmed |
| pubmed-article:20691026 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:20691026 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20691026 | pubmed:articleTitle | Doxorubicin and cyclophosphamide for the treatment of canine lymphoma: a randomized, placebo-controlled study. | lld:pubmed |
| pubmed-article:20691026 | pubmed:affiliation | Animal Cancer Center, Colorado State University College of Veterinary Medicine, Fort Collins, CO 80523-1620, USA. | lld:pubmed |
| pubmed-article:20691026 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20691026 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:20691026 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
