| pubmed-article:20689746 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20689746 | lifeskim:mentions | umls-concept:C0042765 | lld:lifeskim |
| pubmed-article:20689746 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:20689746 | lifeskim:mentions | umls-concept:C0014323 | lld:lifeskim |
| pubmed-article:20689746 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20689746 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20689746 | pubmed:dateCreated | 2010-8-6 | lld:pubmed |
| pubmed-article:20689746 | pubmed:abstractText | It is not understood why only some infections with Entamoeba histolytica result in disease. The calcium-regulated transcription factor upstream regulatory element 3-binding protein (URE3-BP) was initially identified by virtue of its role in regulating the expression of two amebic virulence genes, the Gal/GalNac lectin and ferredoxin. Here we tested whether this transcription factor has a broader role in regulating virulence. A comparison of in vivo to in vitro parasite gene expression demonstrated that 39% of in vivo regulated transcripts contained the URE3 motif recognized by URE3-BP, compared to 23% of all promoters (P < 0.0001). Amebae induced to express a dominant positive mutant form of URE3-BP had an increase in an elongated morphology (30% +/- 6% versus 14% +/- 5%; P = 0.001), a 2-fold competitive advantage at invading the intestinal epithelium (P = 0.017), and a 3-fold increase in liver abscess size (0.1 +/- 0.1 g versus 0.036 +/- 0.1 g; P = 0.03). These results support a role for URE3-BP in virulence regulation. | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20689746 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20689746 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:20689746 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20689746 | pubmed:issn | 2150-7511 | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:ZhangYanY | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:GilchristCaro... | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:MannBarbara... | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:PetriWilliam... | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:LanniganJoann... | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:BousquetChris... | lld:pubmed |
| pubmed-article:20689746 | pubmed:author | pubmed-author:MooreEllyn... | lld:pubmed |
| pubmed-article:20689746 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20689746 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:20689746 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20689746 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20689746 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20689746 | pubmed:articleTitle | Regulation of Virulence of Entamoeba histolytica by the URE3-BP Transcription Factor. | lld:pubmed |
| pubmed-article:20689746 | pubmed:affiliation | Department of Medicine, School of Medicine, University of Virginia, Charlottesville, Virginia, USA. | lld:pubmed |
| pubmed-article:20689746 | pubmed:publicationType | Journal Article | lld:pubmed |
