| pubmed-article:20688526 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C1881708 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C0332472 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C1533716 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C1547179 | lld:lifeskim |
| pubmed-article:20688526 | lifeskim:mentions | umls-concept:C0598002 | lld:lifeskim |
| pubmed-article:20688526 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20688526 | pubmed:dateCreated | 2010-9-24 | lld:pubmed |
| pubmed-article:20688526 | pubmed:abstractText | The formation of c(1) ions during collision-induced fragmentation of peptides with asparagine, ornithine, or glutamine at the N-terminal position 2 has been studied. For this purpose, the corresponding fragment ion spectra of a large set of synthetic peptides were investigated. It is demonstrated that the c(1) ion intensity depends on the nature of the second residue in the N-terminal dipeptide motif as well as on the peptide length. It is shown that the formation of c(1) ions proceeds by two competing mechanisms. One mechanism is the secondary fragmentation of the b(2) ion, the efficiency of which shows only a minor dependency on the complete peptide sequence. The other mechanism is the direct formation from the molecular ion, which is identified to be connected with sequence-specific c(1) ion intensities. A model for this latter mechanism is proposed based on the analysis of the formation and secondary fragmentation of the z(max-1) ion, which is the complementary ion to the c(1) ion. Additional evidence is obtained by investigation of peptides with ornithine in N-terminal position 2, which in general exhibit c(1) ion intensities intermediate between the asparagine- and glutamine-containing species. The data presented support the reliable assignment of N-terminal dipeptide motifs using collision-induced dissociation. | lld:pubmed |
| pubmed-article:20688526 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20688526 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20688526 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20688526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20688526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20688526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20688526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20688526 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20688526 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20688526 | pubmed:issn | 1879-1123 | lld:pubmed |
| pubmed-article:20688526 | pubmed:author | pubmed-author:LehmannWolf... | lld:pubmed |
| pubmed-article:20688526 | pubmed:author | pubmed-author:WinterDominic... | lld:pubmed |
| pubmed-article:20688526 | pubmed:author | pubmed-author:HahnBettinaB | lld:pubmed |
| pubmed-article:20688526 | pubmed:author | pubmed-author:SeidlerJoergJ | lld:pubmed |
| pubmed-article:20688526 | pubmed:copyrightInfo | Copyright © 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20688526 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20688526 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:20688526 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20688526 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20688526 | pubmed:pagination | 1814-20 | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:meshHeading | pubmed-meshheading:20688526... | lld:pubmed |
| pubmed-article:20688526 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20688526 | pubmed:articleTitle | Structural and mechanistic Information on c(1) ion formation in collision-induced fragmentation of peptides. | lld:pubmed |
| pubmed-article:20688526 | pubmed:affiliation | Molecular Structure Analysis, German Cancer Research Center, Heidelberg, Germany. | lld:pubmed |
| pubmed-article:20688526 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20688526 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
