| pubmed-article:20684615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C0074504 | lld:lifeskim |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C1621296 | lld:lifeskim |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:20684615 | lifeskim:mentions | umls-concept:C0815279 | lld:lifeskim |
| pubmed-article:20684615 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:20684615 | pubmed:dateCreated | 2010-8-5 | lld:pubmed |
| pubmed-article:20684615 | pubmed:abstractText | The enantiomers of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [1, (+/-)-PPCC], a selective sigma ligand, were synthesized. The (+)- and (-)-enantiomers bind predominantly to sigma(1) receptors and have a reduced sigma(2) affinity. Both individually restore the astroglial oxidative status modified by glutamate, counteracting also transglutaminase-2 overexpression. They exhibited in vivo anti-opioid effects on kappa opioid (KOP) receptor-mediated analgesia. Our findings demonstrate that the enantiomers display mainly sigma(1) agonist activity and that they have neuroprotective effects. | lld:pubmed |
| pubmed-article:20684615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20684615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20684615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20684615 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20684615 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:PrezzaventoOr... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:RonsisvalleGi... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:BertucciCarlo... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:VanellaAngelo... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:CampisiAgataA | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:ScotoGiovanna... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:ParentiCarmel... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:RonsisvalleSi... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:AricòGiuseppi... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:PistolozziMar... | lld:pubmed |
| pubmed-article:20684615 | pubmed:author | pubmed-author:ArenaEmanuela... | lld:pubmed |
| pubmed-article:20684615 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20684615 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:20684615 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:20684615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20684615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20684615 | pubmed:pagination | 5881-5 | lld:pubmed |
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| pubmed-article:20684615 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20684615 | pubmed:articleTitle | Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effect. | lld:pubmed |
| pubmed-article:20684615 | pubmed:affiliation | Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy. prezzave@unict.it | lld:pubmed |
| pubmed-article:20684615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20684615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20684615 | lld:chembl |
