| pubmed-article:20676042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20676042 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:20676042 | lifeskim:mentions | umls-concept:C0598988 | lld:lifeskim |
| pubmed-article:20676042 | lifeskim:mentions | umls-concept:C0920283 | lld:lifeskim |
| pubmed-article:20676042 | lifeskim:mentions | umls-concept:C1427182 | lld:lifeskim |
| pubmed-article:20676042 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:20676042 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:20676042 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:20676042 | pubmed:dateCreated | 2010-8-17 | lld:pubmed |
| pubmed-article:20676042 | pubmed:abstractText | The gateway for molecular trafficking between the cytoplasm and the nucleus is the Nuclear Pore Complex (NPC). Through mass spectral analysis of the isolated Nuclear Pore Nup107-160 subcomplex, we discovered an in vivo interaction with Werner's Helicase Interacting Protein 1, (WRNIP1 or WHIP). WHIP was originally identified as a binding partner of Werner protein (WRN), which functions to maintain genome stability and is responsible for the progeria disease, Werner syndrome. We established the reciprocal isolation of Nup107 by alpha-WHIP. WHIP was found in purified Nuclear Envelope (NE) fractions treated with DNase/RNase/Heparin. We demonstrated by immunofluorescence microscopy that WHIP is located at the nuclear rim as well as punctate regions in the nuclear matrix. Ultimately, synchronized cells show a dynamic association between WHIP and the Nup107-160 subcomplex through the cell cycle without an interaction with WRN. We thus identify WHIP as a partner/component of the NE/NPC and set forth to investigate a role for the protein positioned at the NPC. | lld:pubmed |
| pubmed-article:20676042 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20676042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20676042 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20676042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20676042 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20676042 | pubmed:issn | 1551-4005 | lld:pubmed |
| pubmed-article:20676042 | pubmed:author | pubmed-author:GlavyJoseph... | lld:pubmed |
| pubmed-article:20676042 | pubmed:author | pubmed-author:KaurSimarnaS | lld:pubmed |
| pubmed-article:20676042 | pubmed:author | pubmed-author:WhiteTommy... | lld:pubmed |
| pubmed-article:20676042 | pubmed:author | pubmed-author:DiGuilioAmand... | lld:pubmed |
| pubmed-article:20676042 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20676042 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20676042 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:20676042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20676042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20676042 | pubmed:pagination | 3106-11 | lld:pubmed |
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| pubmed-article:20676042 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20676042 | pubmed:articleTitle | The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex. | lld:pubmed |
| pubmed-article:20676042 | pubmed:affiliation | Department of Chemistry, Chemical Biology & Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA. | lld:pubmed |
| pubmed-article:20676042 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20676042 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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