| pubmed-article:20675133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20675133 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:20675133 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:20675133 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:20675133 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:20675133 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:20675133 | lifeskim:mentions | umls-concept:C1272745 | lld:lifeskim |
| pubmed-article:20675133 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:20675133 | pubmed:dateCreated | 2010-8-16 | lld:pubmed |
| pubmed-article:20675133 | pubmed:abstractText | SAR studies to improve the selectivity and metabolic stability of a class of recently discovered MMP-13 inhibitors are reported. Improved selectivity was achieved by modifying interactions with the S1' pocket. Metabolic stability was improved through reduction of inhibitor lipophilicity. This translated into lower in vivo clearance for the preferred compound. | lld:pubmed |
| pubmed-article:20675133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20675133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20675133 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20675133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20675133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20675133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20675133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20675133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20675133 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20675133 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:MeeSS | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:LiXiangX | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:WellenzohnBer... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:FarrowNeil... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:MossNeilN | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:TaylorStevenS | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:CaoXianhuaX | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:LiangShuangS | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:CollinsBrando... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:Heim-RietherA... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:ProudfootJohn... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:SchlyerSabine... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:AugustE... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:XiongZhaoming... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:GaoDonghong... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:AmodeoLauraL | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:HavertyKathle... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:Hill-DrzewiMe... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:KeenanLana... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:CiccarelliLeo... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:HarringtonKyl... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:MargaritStelu... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:NagarajaNelam... | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:RomanReneR | lld:pubmed |
| pubmed-article:20675133 | pubmed:author | pubmed-author:WiedenmayerDi... | lld:pubmed |
| pubmed-article:20675133 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20675133 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20675133 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20675133 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:20675133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20675133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20675133 | pubmed:pagination | 5039-43 | lld:pubmed |
| pubmed-article:20675133 | pubmed:meshHeading | pubmed-meshheading:20675133... | lld:pubmed |
| pubmed-article:20675133 | pubmed:meshHeading | pubmed-meshheading:20675133... | lld:pubmed |
| pubmed-article:20675133 | pubmed:meshHeading | pubmed-meshheading:20675133... | lld:pubmed |
| pubmed-article:20675133 | pubmed:meshHeading | pubmed-meshheading:20675133... | lld:pubmed |
| pubmed-article:20675133 | pubmed:meshHeading | pubmed-meshheading:20675133... | lld:pubmed |
| pubmed-article:20675133 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20675133 | pubmed:articleTitle | SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability. | lld:pubmed |
| pubmed-article:20675133 | pubmed:affiliation | Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA. amy.gao@boehringer-ingelheim.com | lld:pubmed |
| pubmed-article:20675133 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20675133 | lld:chembl |
