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pubmed-article:20670304pubmed:abstractTextThe molecular mechanism that contributes to the pathogenesis of deep pressure ulcer remains to be elucidated. This study tested the hypotheses that: (1) apoptosis and autophagy are activated in compression-induced muscle pathology and (2) apoptotic and autophagic changes precede pathohistological changes in skeletal muscle in response to prolonged moderate compression. Methods:? Adult Sprague-Dawley rats were subjected to an experimental model of pressure-induced deep tissue injury. Static pressure of 100 mmHg was applied to an area of 1.5 cm(2) over the mid-tibialis region of right limb of rats for one single session of 6-h compression (1D) or two sessions of 6-h compression over two consecutive days with rats sacrificed one day (2D) or immediately after (2D-IM) the compression. The left uncompressed limb served as the intra-animal control. Muscle tissues underneath compression region were collected for analysis.lld:pubmed
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pubmed-article:20670304pubmed:authorpubmed-author:TamE WEWlld:pubmed
pubmed-article:20670304pubmed:copyrightInfo© 2010 The Authors. Acta Physiologica © 2010 Scandinavian Physiological Society.lld:pubmed
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pubmed-article:20670304pubmed:articleTitleOpposing responses of apoptosis and autophagy to moderate compression in skeletal muscle.lld:pubmed
pubmed-article:20670304pubmed:affiliationDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.lld:pubmed
pubmed-article:20670304pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20670304pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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