| pubmed-article:20661223 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0338106 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20661223 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20661223 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:20661223 | pubmed:dateCreated | 2010-9-24 | lld:pubmed |
| pubmed-article:20661223 | pubmed:abstractText | Sprouty negatively regulates receptor tyrosine kinase signals by inhibiting Ras/extracellular signal-regulated kinase (ERK) pathways. Sprouty is downregulated in breast, prostate and liver cancers and appears to function as a tumor suppressor. The role of sprouty in colonic neoplasia, however, has not been investigated. Sprouty-2 protein and mRNA transcripts were significantly upregulated in human colonic adenocarcinomas. Strikingly, the c-Met receptor was also upregulated in tumors with increased sprouty-2. To delineate a potential causal relationship between sprouty-2 and c-Met, K-ras mutant HCT-116 colon cancer cells were transduced with purified TAT-sprouty-2 protein or stably transfected with full-length human sprouty-2 gene. Sprouty-2 upregulation significantly increased cell proliferation by accelerating cell cycle transition. Sprouty-2 transfectants showed strong upregulation of c-Met protein and mRNA transcripts and hepatocyte growth factor-stimulated ERK and Akt phosphorylation and enhanced cell migration and invasion. In contrast, knockdown of c-Met by small interfering RNA (siRNA) significantly decreased cell proliferation, migration and invasion in sprouty-2 transfectants. Further, knockdown of sprouty-2 by siRNA in parental HT-29 and LS-174T colon cancer cells also decreased cell invasion. Sprouty-2 transfectants formed significantly larger tumor xenografts and showed increased proliferation and angiogenesis and suppressed apoptosis. Sprouty-2 tumors metastasized to the liver from cecal orthotopic implants, suggesting that sprouty-2 might also enhance metastatic signals. Thus, in colon cancer sprouty functions as an oncogene and its effects are mediated in part by c-Met upregulation. | lld:pubmed |
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| pubmed-article:20661223 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20661223 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20661223 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20661223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20661223 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20661223 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20661223 | pubmed:issn | 1476-5594 | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:TaylorII | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:KhareSS | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:JosephLL | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:BissonnetteMM | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:FicheraAA | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:EdwinFF | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:HolgrenCC | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:DoughertyUU | lld:pubmed |
| pubmed-article:20661223 | pubmed:author | pubmed-author:CerasiDD | lld:pubmed |
| pubmed-article:20661223 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20661223 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:20661223 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:20661223 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20661223 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20661223 | pubmed:pagination | 5241-53 | lld:pubmed |
