| pubmed-article:20659111 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20659111 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:20659111 | lifeskim:mentions | umls-concept:C0042672 | lld:lifeskim |
| pubmed-article:20659111 | lifeskim:mentions | umls-concept:C0070745 | lld:lifeskim |
| pubmed-article:20659111 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20659111 | pubmed:dateCreated | 2010-7-27 | lld:pubmed |
| pubmed-article:20659111 | pubmed:abstractText | Nine simplified vinca alkaloids and phomospin A hybrids, in which vindoline moiety has been replaced by a simpler scaffold, have been elaborated to evaluate their activity on the inhibition of tubulin polymerization. This article deals with the synthesis of various simplified vinca alkaloids, using a stereoselective coupling of catharantine with reactive aromatic compounds and methanol as well as their subsequent condensation with a large peptide chain mimicking those of phomopsin A. Biological evaluation and molecular modeling studies are also reported. | lld:pubmed |
| pubmed-article:20659111 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20659111 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20659111 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20659111 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20659111 | pubmed:issn | 1747-0285 | lld:pubmed |
| pubmed-article:20659111 | pubmed:author | pubmed-author:GuéritteFranç... | lld:pubmed |
| pubmed-article:20659111 | pubmed:author | pubmed-author:ThoretSylvian... | lld:pubmed |
| pubmed-article:20659111 | pubmed:author | pubmed-author:RoussiFannyF | lld:pubmed |
| pubmed-article:20659111 | pubmed:author | pubmed-author:NgoQuoc AnhQA | lld:pubmed |
| pubmed-article:20659111 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20659111 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:20659111 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20659111 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20659111 | pubmed:pagination | 284-94 | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:meshHeading | pubmed-meshheading:20659111... | lld:pubmed |
| pubmed-article:20659111 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20659111 | pubmed:articleTitle | Elaboration of simplified vinca alkaloids and phomopsin hybrids. | lld:pubmed |
| pubmed-article:20659111 | pubmed:affiliation | Centre de recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France. | lld:pubmed |
| pubmed-article:20659111 | pubmed:publicationType | Journal Article | lld:pubmed |
