| pubmed-article:20651376 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0694898 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:20651376 | lifeskim:mentions | umls-concept:C0522503 | lld:lifeskim |
| pubmed-article:20651376 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20651376 | pubmed:dateCreated | 2010-7-23 | lld:pubmed |
| pubmed-article:20651376 | pubmed:abstractText | Clinical studies of WT1-targeted cancer vaccine are being performed. However, WT1-specific Th response in cancer patients remains unclear. Using quantitative real-time RT-PCR, we investigated IFN-gamma and IL-10 mRNA expression from Th cells by stimulation with helper peptide WT1(332). Seventeen patients, of whom 10 had achieved stable disease and the remaining 7 had progressive disease, were weekly vaccinated with WT1 CTL epitope (modified WT1(235)) and examined for WT1(332)-specific Th response. A clear correlation between WT1(332)-specific Th response and clinical response was observed at 4 weeks post-vaccination. In patients who responded, a clear inverse correlation between IL-10-type and IFN-gamma-type WT1(332)-specific Th response was detected at pre- and 4 weeks post-vaccination, and the shift of the Th response from IL-10-type dominancy at early phase to IFN-gamma-type dominancy at late phase was observed. From this study we concluded that occurrence of WT1(332)-specific Th response could predict good clinical response of WT1 CTL epitope vaccination. | lld:pubmed |
| pubmed-article:20651376 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20651376 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20651376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20651376 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20651376 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20651376 | pubmed:issn | 1791-7530 | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:KawaseIchiroI | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:MyouiAkiraA | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:OkuyamaAkihik... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:TaguchiTetsuy... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:NoguchiShinza... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:MarunoMotohik... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:YoshimineTosh... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:HosenNaokiN | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:OjiYusukeY | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:TsuboiAkihiro... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:OkaYoshihiroY | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:SugiyamaHaruo... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:NonomuraNorio... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:ItoToshinoriT | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:TakedaYutakaY | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:HashimotoNaoy... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:NishidaSumiyu... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:NakajimaHirok... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:IzumotoShuich... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:FujikiFumihir... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:TatsumiNaoyaN | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:ShirakataTosh... | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:UedaSatsukiS | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:KawakatsuMaiM | lld:pubmed |
| pubmed-article:20651376 | pubmed:author | pubmed-author:Tanaka-Harada... | lld:pubmed |
| pubmed-article:20651376 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20651376 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:20651376 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20651376 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20651376 | pubmed:pagination | 2247-54 | lld:pubmed |
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| pubmed-article:20651376 | pubmed:meshHeading | pubmed-meshheading:20651376... | lld:pubmed |
| pubmed-article:20651376 | pubmed:meshHeading | pubmed-meshheading:20651376... | lld:pubmed |
| pubmed-article:20651376 | pubmed:meshHeading | pubmed-meshheading:20651376... | lld:pubmed |
| pubmed-article:20651376 | pubmed:meshHeading | pubmed-meshheading:20651376... | lld:pubmed |
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| pubmed-article:20651376 | pubmed:meshHeading | pubmed-meshheading:20651376... | lld:pubmed |
| pubmed-article:20651376 | pubmed:meshHeading | pubmed-meshheading:20651376... | lld:pubmed |
| pubmed-article:20651376 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20651376 | pubmed:articleTitle | A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination. | lld:pubmed |
| pubmed-article:20651376 | pubmed:affiliation | Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 1-7, Yamada-Oka, Suita City, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:20651376 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20651376 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
