| pubmed-article:20651254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20651254 | lifeskim:mentions | umls-concept:C0278488 | lld:lifeskim |
| pubmed-article:20651254 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:20651254 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:20651254 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:20651254 | pubmed:dateCreated | 2010-9-2 | lld:pubmed |
| pubmed-article:20651254 | pubmed:abstractText | Current treatment for late-stage metastatic breast cancer is largely palliative. alpha-Particles are highly potent, short-range radiation emissions capable of sterilizing individual cells with one to three traversals of the cell nucleus. The alpha-emitter, (213)Bi (T(1/2) = 45.6 min), was conjugated to a 100-nm diameter liposomal-CHX-A''-DTPA construct, upon which the rat HER2/neu reactive antibody, 7.16.4, was grafted. A conjugation time of 10 minutes was achieved giving a specific activity corresponding to 0.1 (213)Bi atom per liposome; stability in vitro and in vivo was confirmed. Efficacy in a rat/neu transgenic mouse model of metastatic mammary carcinoma was investigated. Three days after left cardiac ventricular injection of 10(5) rat HER-2/neu-expressing syngeneic tumor cells, macrophage-depleted Neu-N mice were treated by i.v. injection with (a) 19.2 MBq (520 muCi) of liposome-CHX-A''-DTPA-(213)Bi, (b) 19.2 MBq of liposome-CHX-A''-DTPA-(213)Bi-7.16.4, (c) 4.44 MBq (120 muCi) of (213)Bi-7.16.4, and (d) cold (nonradioactive) liposome-CHX-A''-DTPA-7.16.4 as control. Treatment with (a) increased median survival time to 34 days compared with 29 days for the untreated controls (P = 0.013) and 27 days for treated cold controls. Treatment with the radiolabeled antibody-conjugated liposome (b) increased median survival time to 38 days (P = 0.0002 relative to untreated controls). The radiolabeled antibody-treated group (c) gave a median survival of 39 days, which was similar to that for the radiolabeled antibody-conjugated liposome-treated group (P = 0.5). We have shown that the (213)Bi radiolabeled immunoliposomes are effective in treating early-stage micrometastases, giving median survival times similar to those obtained with antibody-mediated delivery of (213)Bi in this animal model. | lld:pubmed |
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| pubmed-article:20651254 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20651254 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20651254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20651254 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20651254 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:20651254 | pubmed:author | pubmed-author:SgourosGeorge... | lld:pubmed |
| pubmed-article:20651254 | pubmed:author | pubmed-author:SongHongH | lld:pubmed |
| pubmed-article:20651254 | pubmed:author | pubmed-author:ThompsonSarah... | lld:pubmed |
| pubmed-article:20651254 | pubmed:author | pubmed-author:MorgensternAl... | lld:pubmed |
| pubmed-article:20651254 | pubmed:author | pubmed-author:Bruchertseife... | lld:pubmed |
| pubmed-article:20651254 | pubmed:author | pubmed-author:LingappaMohan... | lld:pubmed |
| pubmed-article:20651254 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20651254 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20651254 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:20651254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20651254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20651254 | pubmed:pagination | 6815-23 | lld:pubmed |
| pubmed-article:20651254 | pubmed:dateRevised | 2011-9-13 | lld:pubmed |
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| pubmed-article:20651254 | pubmed:meshHeading | pubmed-meshheading:20651254... | lld:pubmed |
| pubmed-article:20651254 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20651254 | pubmed:articleTitle | Immunoliposomal delivery of 213Bi for alpha-emitter targeting of metastatic breast cancer. | lld:pubmed |
| pubmed-article:20651254 | pubmed:affiliation | Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA. | lld:pubmed |
| pubmed-article:20651254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20651254 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:20651254 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
