pubmed-article:20628002 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0174680 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0056557 | lld:lifeskim |
pubmed-article:20628002 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:20628002 | pubmed:issue | 8 | lld:pubmed |
pubmed-article:20628002 | pubmed:dateCreated | 2010-8-6 | lld:pubmed |
pubmed-article:20628002 | pubmed:abstractText | Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G(1)-G(0) phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, we found that CPT inhibited the signaling pathway of the mammalian target of rapamycin (mTOR), a central regulator of cell proliferation. This is evidenced by the findings that CPT inhibited type I insulin-like growth factor I- or 10% fetal bovine serum-stimulated phosphorylation of mTOR, p70 S6 kinase 1, and eukaryotic initiation factor 4E binding protein 1 in a concentration- and time-dependent manner. Expression of constitutively active mTOR conferred resistance to CPT inhibition of cyclin D1 expression and Rb phosphorylation, as well as cell growth. The results suggest that CPT is a novel antiproliferative agent. | lld:pubmed |
pubmed-article:20628002 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:language | eng | lld:pubmed |
pubmed-article:20628002 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20628002 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20628002 | pubmed:month | Aug | lld:pubmed |
pubmed-article:20628002 | pubmed:issn | 1940-6215 | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:RAOT TTT | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:WanSS | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:RoweC TCT | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:HuangShileS | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:LuoYanY | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:LiuZhijunZ | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:HanXiuzhenX | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:ZhouHongyuH | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:XuBaoshanB | lld:pubmed |
pubmed-article:20628002 | pubmed:author | pubmed-author:ChenWenxingW | lld:pubmed |
pubmed-article:20628002 | pubmed:copyrightInfo | 2010 AACR. | lld:pubmed |
pubmed-article:20628002 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20628002 | pubmed:volume | 3 | lld:pubmed |
pubmed-article:20628002 | pubmed:owner | NLM | lld:pubmed |