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pubmed-article:20627934pubmed:abstractTextSeveral transcription factors are essential to pancreatic islet ?-cell development, proliferation, and activity, including MafA and MafB. However, MafA and MafB are distinct from others in regard to temporal and islet cell expression pattern, with ?-cells affected by MafB only during development and exclusively by MafA in the adult. Our aim was to define the functional relationship between these closely related activators to the ?-cell.lld:pubmed
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pubmed-article:20627934pubmed:articleTitleMafA and MafB regulate genes critical to beta-cells in a unique temporal manner.lld:pubmed
pubmed-article:20627934pubmed:affiliationDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. isabella.artner@med.lu.selld:pubmed
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