| pubmed-article:20620516 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20620516 | lifeskim:mentions | umls-concept:C0023911 | lld:lifeskim |
| pubmed-article:20620516 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:20620516 | lifeskim:mentions | umls-concept:C0072980 | lld:lifeskim |
| pubmed-article:20620516 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20620516 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:20620516 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:20620516 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20620516 | pubmed:dateCreated | 2010-7-12 | lld:pubmed |
| pubmed-article:20620516 | pubmed:abstractText | Rapamycin can promote the generation and homeostasis of CD4(+)Foxp3(+) regulatory T cells (Tregs) both in vitro and in vivo. The mechanisms by which rapamycin mediates this effect are poorly defined. In this study, we characterized CD4(+)Foxp3(+) Tregs in liver grafts and peripheral blood following rapamycin treatment using a syngeneic liver transplant model. Orthotopic liver transplantation was performed from Lewis (LEW) to LEW rats. In the first 2 weeks the percentage of CD4(+)Foxp3(+) Tregs was increased in the liver grafts and blood only among the rapamycin group compared with control group. Conversely, the percentage of CD4(+)Foxp3(+) Tregs in the liver graft and blood decreased in the cyclosporine group. In normal rats, rapamycin did not impact the generation of CD4(+)Foxp3(+) Tregs in the thymus. Thus, rapamycin can significantly enhance the percentages of CD4(+)Foxp3(+) Tregs in the thymus and periphery, indicating that rapamycin favors Tregs expansion and may suppress other CD4(+) T cells. | lld:pubmed |
| pubmed-article:20620516 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20620516 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20620516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620516 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20620516 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20620516 | pubmed:issn | 1873-2623 | lld:pubmed |
| pubmed-article:20620516 | pubmed:author | pubmed-author:MOGG | lld:pubmed |
| pubmed-article:20620516 | pubmed:author | pubmed-author:ZhangFF | lld:pubmed |
| pubmed-article:20620516 | pubmed:author | pubmed-author:WangX HXH | lld:pubmed |
| pubmed-article:20620516 | pubmed:author | pubmed-author:ZhengS GSG | lld:pubmed |
| pubmed-article:20620516 | pubmed:author | pubmed-author:QianX FXF | lld:pubmed |
| pubmed-article:20620516 | pubmed:author | pubmed-author:RaoJ HJH | lld:pubmed |
| pubmed-article:20620516 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20620516 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:20620516 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20620516 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20620516 | pubmed:pagination | 1755-7 | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:meshHeading | pubmed-meshheading:20620516... | lld:pubmed |
| pubmed-article:20620516 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20620516 | pubmed:articleTitle | Rapamycin promotes the expansion of CD4(+) Foxp3(+) regulatory T cells after liver transplantation. | lld:pubmed |
| pubmed-article:20620516 | pubmed:affiliation | Division of Liver Transplantation Center, Nanjing Medical University, Nanjing, China. | lld:pubmed |
| pubmed-article:20620516 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20620516 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20620516 | lld:pubmed |
