Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20616208rdf:typepubmed:Citationlld:pubmed
pubmed-article:20616208lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:20616208lifeskim:mentionsumls-concept:C0016693lld:lifeskim
pubmed-article:20616208lifeskim:mentionsumls-concept:C0043335lld:lifeskim
pubmed-article:20616208lifeskim:mentionsumls-concept:C0017982lld:lifeskim
pubmed-article:20616208lifeskim:mentionsumls-concept:C0079411lld:lifeskim
pubmed-article:20616208lifeskim:mentionsumls-concept:C1407029lld:lifeskim
pubmed-article:20616208pubmed:issue2lld:pubmed
pubmed-article:20616208pubmed:dateCreated2010-9-17lld:pubmed
pubmed-article:20616208pubmed:abstractTextFree radicals generated during peroxidase-catalyzed oxidation of two xenobiotics, carcinogenic Sudan I and an anticancer agent ellipticine, easily attack unmodified proteins but not glycoproteins. A significant inverse correlation between the extent of glycosylation of proteins and the degree of binding of Sudan I or ellipticine radicals to these proteins was observed, whereby the protection only occurs if oligosaccharides are covalently bound to the proteins. No influence of any other variables was found and further confirmed by experiments with proteins containing identical polypeptide chains differing only by the absence (ribonuclease A) or the presence (ribonuclease B) of a single oligosaccharide. The free radicals that are subject of this study did not react with the oligosaccharides because higher levels of the corresponding dimers, reaction products of the radicals, were found in presence of highly glycosylated proteins. The results indicate that carbohydrates protect polypeptides against modification by free radicals derived from toxic xenobiotics and provide passive shielding of the protein moiety.lld:pubmed
pubmed-article:20616208pubmed:languageenglld:pubmed
pubmed-article:20616208pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:citationSubsetIMlld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20616208pubmed:statusMEDLINElld:pubmed
pubmed-article:20616208pubmed:monthOctlld:pubmed
pubmed-article:20616208pubmed:issn1096-0929lld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:StiborováMari...lld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:FreiEvaElld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:HofbauerováKa...lld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:BezouskaKarel...lld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:MartínekVácla...lld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:SulcMiroslavMlld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:SklenárJanJlld:pubmed
pubmed-article:20616208pubmed:authorpubmed-author:DracínskyMart...lld:pubmed
pubmed-article:20616208pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20616208pubmed:volume117lld:pubmed
pubmed-article:20616208pubmed:ownerNLMlld:pubmed
pubmed-article:20616208pubmed:authorsCompleteYlld:pubmed
pubmed-article:20616208pubmed:pagination359-74lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:meshHeadingpubmed-meshheading:20616208...lld:pubmed
pubmed-article:20616208pubmed:year2010lld:pubmed
pubmed-article:20616208pubmed:articleTitleGlycosylation protects proteins against free radicals generated from toxic xenobiotics.lld:pubmed
pubmed-article:20616208pubmed:affiliationDepartment of Biochemistry, Faculty of Science, Charles University Prague, 12840 Prague 2, Czech Republic.lld:pubmed
pubmed-article:20616208pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20616208pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed