| pubmed-article:20616007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0029433 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0205107 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C1120843 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C1538046 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C0443281 | lld:lifeskim |
| pubmed-article:20616007 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:20616007 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:20616007 | pubmed:dateCreated | 2010-7-21 | lld:pubmed |
| pubmed-article:20616007 | pubmed:abstractText | The neighbor of Brca1 gene (Nbr1) functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation. It also has a dual role as a scaffold protein to regulate growth-factor receptor and downstream signaling pathways. We show that genetic truncation of murine Nbr1 leads to an age-dependent increase in bone mass and bone mineral density through increased osteoblast differentiation and activity. At 6 mo of age, despite normal body size, homozygous mutant animals (Nbr1(tr/tr)) have approximately 50% more bone than littermate controls. Truncated Nbr1 (trNbr1) co-localizes with p62, a structurally similar interacting scaffold protein, and the autophagosome marker LC3 in osteoblasts, but unlike the full-length protein, trNbr1 fails to complex with activated p38 MAPK. Nbr1(tr/tr) osteoblasts and osteoclasts show increased activation of p38 MAPK, and significantly, pharmacological inhibition of the p38 MAPK pathway in vitro abrogates the increased osteoblast differentiation of Nbr1(tr/tr) cells. Nbr1 truncation also leads to increased p62 protein expression. We show a role for Nbr1 in bone remodeling, where loss of function leads to perturbation of p62 levels and hyperactivation of p38 MAPK that favors osteoblastogenesis. | lld:pubmed |
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| pubmed-article:20616007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20616007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20616007 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20616007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20616007 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20616007 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:SolomonEllenE | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:SharpePaul... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:HornerAlanA | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:CobourneMarty... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:WhitehouseCar... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:GrigoriadisAg... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:McGowanNeil... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:SkerryTim MTM | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:WatersSarahS | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:XavierGuilher... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:JovanovicJele... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:KashimaTakesh... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:MarchbankKati... | lld:pubmed |
| pubmed-article:20616007 | pubmed:author | pubmed-author:RichardsGaret... | lld:pubmed |
| pubmed-article:20616007 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20616007 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:20616007 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20616007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20616007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20616007 | pubmed:pagination | 12913-8 | lld:pubmed |
| pubmed-article:20616007 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
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