| pubmed-article:20614889 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C0072899 | lld:lifeskim |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:20614889 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20614889 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:20614889 | pubmed:dateCreated | 2010-8-5 | lld:pubmed |
| pubmed-article:20614889 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:abstractText | A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS penetration. These discoveries led to 17i, a potent, efficacious CNS penetrant molecule with an excellent pharmacokinetic profile across preclinical species, which is well tolerated and is also orally bioavailable in humans. | lld:pubmed |
| pubmed-article:20614889 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20614889 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20614889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20614889 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20614889 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20614889 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:ProfetaRobert... | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:AldegheriLaur... | lld:pubmed |
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| pubmed-article:20614889 | pubmed:author | pubmed-author:YusafShahnaz... | lld:pubmed |
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| pubmed-article:20614889 | pubmed:author | pubmed-author:SmithPaul WPW | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:WardSimon ESE | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:MookherjeeCla... | lld:pubmed |
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| pubmed-article:20614889 | pubmed:author | pubmed-author:BallantineStu... | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:HarrisAndrew... | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:LundJesperJ | lld:pubmed |
| pubmed-article:20614889 | pubmed:author | pubmed-author:MelarangeRose... | lld:pubmed |
| pubmed-article:20614889 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20614889 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:20614889 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:20614889 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20614889 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20614889 | pubmed:pagination | 5801-12 | lld:pubmed |
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| pubmed-article:20614889 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20614889 | pubmed:articleTitle | Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. | lld:pubmed |
| pubmed-article:20614889 | pubmed:affiliation | Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK. simon.e.ward@gsk.com | lld:pubmed |
| pubmed-article:20614889 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20614889 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20614889 | lld:chembl |
