| pubmed-article:20613485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20613485 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:20613485 | lifeskim:mentions | umls-concept:C1366521 | lld:lifeskim |
| pubmed-article:20613485 | lifeskim:mentions | umls-concept:C1149234 | lld:lifeskim |
| pubmed-article:20613485 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:20613485 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20613485 | pubmed:dateCreated | 2010-7-30 | lld:pubmed |
| pubmed-article:20613485 | pubmed:abstractText | The novel cytokine melanoma differentiation associated gene-7 (mda-7) was identified by subtractive hybridization in the mid-1990s as a protein whose expression increased during the induction of terminal differentiation, and that was either not expressed or was present at low levels in tumor cells compared with non-transformed cells. On the basis of conserved structure, chromosomal location and cytokine-like properties, MDA-7, has now been classified as a member of the expanding interleukin (IL)-10 gene family and designated as MDA-7/IL-24. Multiple studies have shown that the expression of MDA-7/IL-24 in a wide variety of tumor cell types, but not in the corresponding equivalent non-transformed cells, causes their growth arrest and ultimately cell death. In addition, MDA-7/IL-24 has been noted to be a radiosensitizing cytokine, which is partly because of the generation of reactive oxygen species and ceramide that cause endoplasmic reticulum stress. Phase I clinical trial data has shown that a recombinant adenovirus expressing MDA-7/IL-24 [Ad.mda-7 (INGN-241)] was safe and had measurable tumoricidal effects in over 40% of patients, which strongly argues that MDA-7/IL-24 may have significant therapeutic value. This review describes what is known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications. | lld:pubmed |
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| pubmed-article:20613485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20613485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20613485 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20613485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20613485 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20613485 | pubmed:issn | 1473-5741 | lld:pubmed |
| pubmed-article:20613485 | pubmed:author | pubmed-author:DentPaulP | lld:pubmed |
| pubmed-article:20613485 | pubmed:author | pubmed-author:CurielDavid... | lld:pubmed |
| pubmed-article:20613485 | pubmed:author | pubmed-author:RahmaniMohame... | lld:pubmed |
