| pubmed-article:20600471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C1556095 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C0005586 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C0558295 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C1413503 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C1707418 | lld:lifeskim |
| pubmed-article:20600471 | lifeskim:mentions | umls-concept:C1548789 | lld:lifeskim |
| pubmed-article:20600471 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20600471 | pubmed:dateCreated | 2010-9-13 | lld:pubmed |
| pubmed-article:20600471 | pubmed:abstractText | Genes associated with circadian rhythms have been suggested to play an important role in the pathophysiology of bipolar disorder. A single nucleotide polymorphism (SNP) in the 3'-flanking region of CLOCK (3111T/C; rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder. We examined the association of CLOCK 3111T/C with bipolar disorder in 260 patients and 350 controls in a Korean population. CLOCK 3111T/C showed significant allelic and genotypic associations with bipolar disorder (P=0.012, P=0.033, respectively). Morningness/eveningness (M/E) was evaluated using the Composite Scale of Morningness (CSM) in 108 patients with bipolar disorder. In the subgroup analysis of the highest and lowest 25th percentile of M/E scores, significantly more C allele carriers were found among extreme evening types than among extreme morning types (P=0.041). After correcting for age, C allele carriers had lower M/E scores than those carrying the T/T genotype, but the association was not statistically significant. We also analyzed the association between age at onset (AAO) and CLOCK 3111T/C in the bipolar disorder group, and no association was found. Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder. Further studies with larger samples and more polymorphisms are necessary. | lld:pubmed |
| pubmed-article:20600471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20600471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600471 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20600471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20600471 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20600471 | pubmed:issn | 1878-4216 | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:KimYong SikYS | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:AhnYong MinYM | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:KimSe HyunSH | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:LeeKyu... | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:JooEun-JeongE... | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:KimSeong... | lld:pubmed |
| pubmed-article:20600471 | pubmed:author | pubmed-author:SongJoo YunJY | lld:pubmed |
| pubmed-article:20600471 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20600471 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20600471 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20600471 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:20600471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20600471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20600471 | pubmed:pagination | 1196-201 | lld:pubmed |
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| pubmed-article:20600471 | pubmed:meshHeading | pubmed-meshheading:20600471... | lld:pubmed |
| pubmed-article:20600471 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20600471 | pubmed:articleTitle | Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder. | lld:pubmed |
| pubmed-article:20600471 | pubmed:affiliation | Department of Neuropsychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea. | lld:pubmed |
| pubmed-article:20600471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20600471 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:9575 | entrezgene:pubmed | pubmed-article:20600471 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20600471 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20600471 | lld:entrezgene |
