Linked Life Data

20600458

Source:http://linkedlifedata.com/resource/pubmed/id/20600458

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pubmed-article:20600458pubmed:dateCreated2010-10-11lld:pubmed
pubmed-article:20600458pubmed:abstractTextThe present study defined a simplified physiologically based pharmacokinetic (PBPK) model for acrylonitrile in humans based on in vitro metabolic parameters determined using relevant liver microsomes, coefficients derived in silico, physiological parameters derived from the literature, and a prior previously developed PBPK model in rats. The model basically consists of a chemical absorption compartment, a metabolizing compartment, and a central compartment for acrylonitrile. Evaluation of a previous rat model was performed by comparisons with experimental pharmacokinetic values from blood and urine obtained from rats in vivo after oral treatment with acrylonitrile (30 mg/kg, a no-observed-adverse-effect level) for 14 days. Elimination rates of acrylonitrile in vitro were established using data from rat liver microsomes and from pooled human liver microsomes. Acrylonitrile was expected to be absorbed and cleared rapidly from the body in silico, as was the case for rats confirmed experimentally in vivo with repeated low-dose treatments. These results indicate that the simplified PBPK model for acrylonitrile is useful for a forward dosimetry approach in humans. This model may also be useful for simulating blood concentrations of other related compounds resulting from exposure to low chemical doses.lld:pubmed
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pubmed-article:20600458pubmed:authorpubmed-author:YamazakiHiros...lld:pubmed
pubmed-article:20600458pubmed:authorpubmed-author:MurayamaNorie...lld:pubmed
pubmed-article:20600458pubmed:authorpubmed-author:TakanoRyohjiRlld:pubmed
pubmed-article:20600458pubmed:authorpubmed-author:KitajimaMasat...lld:pubmed
pubmed-article:20600458pubmed:authorpubmed-author:HoriuchiKanaKlld:pubmed
pubmed-article:20600458pubmed:authorpubmed-author:ShonoFumiakiFlld:pubmed
pubmed-article:20600458pubmed:authorpubmed-author:KumamotoMasat...lld:pubmed
pubmed-article:20600458pubmed:copyrightInfoCopyright © 2010 Elsevier Inc. All rights reserved.lld:pubmed
pubmed-article:20600458pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20600458pubmed:volume58lld:pubmed
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pubmed-article:20600458pubmed:articleTitleBlood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling.lld:pubmed
pubmed-article:20600458pubmed:affiliationLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.lld:pubmed
pubmed-article:20600458pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20600458pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed