| pubmed-article:20600242 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0238598 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0034700 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C1517084 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0035868 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0205092 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:20600242 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:20600242 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20600242 | pubmed:dateCreated | 2010-8-30 | lld:pubmed |
| pubmed-article:20600242 | pubmed:abstractText | Preclinical modeling of Parkinson's disease using 6-hydroxydopamine (6-OHDA) has been valuable in developing and testing therapeutic strategies. Recent efforts have focused on modeling early stages of disease by infusing 6-OHDA into the striatum. The partial DA depletion that follows intrastriatal 6-OHDA is more variable than the near-complete depletion following medial forebrain bundle infusion, and behavioral screening assays are not as well characterized in the partial lesion model. We compared relationships between amphetamine-elicited rotation behavior and DA depletion following intrastriatal 6-OHDA (12.5 microg) in 6 month vs. 18 month F344/BN rats, at 2-weeks and 6-weeks post-lesion. We compared the total number of rotations with within-session (bin-by-bin) parameters of rotation behavior as indicators of DA depletion. Striatal DA depletion was greater in the young adult than in the middle-aged rats at 2 weeks but not at 6 weeks post-lesion. The total number of rotations for the whole session and striatal DA depletion did not differ between the two age groups. Regression analysis revealed a greater relationship between within-session parameters of rotation behavior and DA depletion in the middle-aged group than in the young adult group. These results have implications for estimating DA depletion in preclinical studies using rats of different ages. | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20600242 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20600242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600242 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20600242 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20600242 | pubmed:issn | 1873-5177 | lld:pubmed |
| pubmed-article:20600242 | pubmed:author | pubmed-author:StanfordJohn... | lld:pubmed |
| pubmed-article:20600242 | pubmed:author | pubmed-author:FowlerStephen... | lld:pubmed |
| pubmed-article:20600242 | pubmed:author | pubmed-author:ZhangHongyuH | lld:pubmed |
| pubmed-article:20600242 | pubmed:author | pubmed-author:ChertoffMark... | lld:pubmed |
| pubmed-article:20600242 | pubmed:author | pubmed-author:WatsonG... | lld:pubmed |
| pubmed-article:20600242 | pubmed:author | pubmed-author:Bethel-BrownC... | lld:pubmed |
| pubmed-article:20600242 | pubmed:copyrightInfo | (c) 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20600242 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20600242 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:20600242 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20600242 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20600242 | pubmed:pagination | 423-8 | lld:pubmed |
| pubmed-article:20600242 | pubmed:dateRevised | 2011-10-3 | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:meshHeading | pubmed-meshheading:20600242... | lld:pubmed |
| pubmed-article:20600242 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20600242 | pubmed:articleTitle | Within-session analysis of amphetamine-elicited rotation behavior reveals differences between young adult and middle-aged F344/BN rats with partial unilateral striatal dopamine depletion. | lld:pubmed |
| pubmed-article:20600242 | pubmed:affiliation | Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. | lld:pubmed |
| pubmed-article:20600242 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20600242 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20600242 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
