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pubmed-article:20598742pubmed:abstractTextPharmacologic differentiating agents have had relatively limited clinical success outside of the use of ATRA in acute promyelocytic leukemia and DNA methyltransferase inhibitors in myelodysplastic syndromes. The differentiating effects of such agents can be enhanced in combination with lineage-specific growth factors. We developed a dose finding trial to assess toxicity, differentiating activity, and clinical impact of the combination of bryostatin-1 and GM-CSF.lld:pubmed
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pubmed-article:20598742pubmed:copyrightInfoCopyright © 2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20598742pubmed:articleTitleDifferentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.lld:pubmed
pubmed-article:20598742pubmed:affiliationJohns Hopkins Medical Institute, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA. bdsmith@jhmi.edulld:pubmed
pubmed-article:20598742pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20598742pubmed:publicationTypeClinical Triallld:pubmed
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