| pubmed-article:20596257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C0301944 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C2323499 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C1332823 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C0662900 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:20596257 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:20596257 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20596257 | pubmed:dateCreated | 2010-7-2 | lld:pubmed |
| pubmed-article:20596257 | pubmed:abstractText | The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine receptors plays an important role in hematopoiesis following hematopoietic stem cell transplantation. We examined the efficacy of post transplant administration of a specific CXCR4 antagonist (AMD3100) in improving animal survival and in enhancing donor hematopoietic cell engraftment using a congeneic mouse transplantation model. AMD3100 was administered subcutaneously at 5 mg/kg body weight 3 times a week beginning at day +2 post-transplant. Post-transplant administration of AMD3100 significantly improves animal survival. AMD3100 reduces pro-inflammatory cytokine/chemokine production. Furthermore, post transplant administration of AMD3100 selectively enhances donor cell engraftment and promotes recovery of all donor cell lineages (myeloid cells, T and B lymphocytes, erythrocytes and platelets). This enhancement results from a combined effect of increased marrow niche availability and greater cell division induced by AMD3100. Our studies shed new lights into the biological roles of SDF-1/CXCR4 interaction in hematopoietic stem cell engraftment following transplantation and in transplant-related mortality. Our results indicate that AMD3100 provides a novel approach for enhancing hematological recovery following transplantation, and will likely benefit patients undergoing transplantation. | lld:pubmed |
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| pubmed-article:20596257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20596257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596257 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20596257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20596257 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:20596257 | pubmed:author | pubmed-author:ChenBenny JBJ | lld:pubmed |
| pubmed-article:20596257 | pubmed:author | pubmed-author:ChaoNelson... | lld:pubmed |
| pubmed-article:20596257 | pubmed:author | pubmed-author:KangYubinY | lld:pubmed |
| pubmed-article:20596257 | pubmed:author | pubmed-author:DeoliveiraDiv... | lld:pubmed |
| pubmed-article:20596257 | pubmed:author | pubmed-author:MitoJeffreyJ | lld:pubmed |
| pubmed-article:20596257 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20596257 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:20596257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20596257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20596257 | pubmed:pagination | e11316 | lld:pubmed |
| pubmed-article:20596257 | pubmed:dateRevised | 2010-9-30 | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:meshHeading | pubmed-meshheading:20596257... | lld:pubmed |
| pubmed-article:20596257 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20596257 | pubmed:articleTitle | Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. | lld:pubmed |
| pubmed-article:20596257 | pubmed:affiliation | Divisions of Hematology, Oncology and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America. | lld:pubmed |
| pubmed-article:20596257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20596257 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20596257 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20596257 | lld:pubmed |
