| pubmed-article:205867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0028630 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0034801 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:205867 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:205867 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:205867 | pubmed:dateCreated | 1978-6-17 | lld:pubmed |
| pubmed-article:205867 | pubmed:abstractText | This study shows that nucleotides, as well as ions, regulate the opiate receptors of brain. GMP-P(NH)P and Na(+) reduce the amount of steady-state specific [(3)H]dihydromorphine binding and increase the rate of dissociation of the ligand from the opiate receptor. In contrast, Mn(2+) decreases the rate of ligand dissociation and antagonizes the ability of Na(+) to increase dissociation. The effects of GMP-P(NH)P on steady-state binding and dissociation are not reversed by washing. Only GTP, GDP, ITP, and IMP-P(NH)P, in addition to GMP-P(NH)P, increase the rate of dihydromorphine dissociation. The site of nucleotide action appears to have high affinity: <1 muM GMP-P(NH)P produces half-maximal increases in ligand dissociation. GMP-P(NH)P- and Na(+)-directed increases in dissociation have also been found for the opiate agonists [(3)H]etorphine, [(3)H]Leu-enkephalin, and [(3)H]Met-enkephalin and the opiate antagonist [(3)H]naltrexone. Mn(2+)-directed decreases in dissociation have been found for the agonist [(3)H]-etorphine and the antagonist [(3)H]naltrexone. Although the plasma membrane receptors for a number of other neuro-transmitters and hormones are also regulated by guanine nucleotides, the opiate receptors appear unique because only they show nucleotide regulation of both agonist and antagonist binding. | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:205867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:205867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:205867 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:205867 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:205867 | pubmed:author | pubmed-author:BlumeA JAJ | lld:pubmed |
| pubmed-article:205867 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:205867 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:205867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:205867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:205867 | pubmed:pagination | 1713-7 | lld:pubmed |
| pubmed-article:205867 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-A... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-B... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-M... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-M... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-R... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-S... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-M... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-M... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-R... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-L... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-E... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-N... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-R... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-E... | lld:pubmed |
| pubmed-article:205867 | pubmed:meshHeading | pubmed-meshheading:205867-G... | lld:pubmed |
| pubmed-article:205867 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:205867 | pubmed:articleTitle | Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides. | lld:pubmed |
| pubmed-article:205867 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:205867 | lld:pubmed |
